Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.330 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.330 Biomarker PSYGENET Rs7565981 (p = 4.2 × 10(-8)) is in an intergenic region upstream of the neuronal PAS (per-ARNT-sim) domain-containing protein 2 gene (NPAS2), a regulatory gene belonging to a family of transcription factors that has been implicated in memory, seasonal affective disorder, and the molecular clock in the mammalian forebrain. 22137330

2012

Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.330 Biomarker PSYGENET Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders. 21835597

2011

Entrez Id: 4862
Gene Symbol: NPAS2
NPAS2
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.330 Biomarker PSYGENET Certain allelic combinations of NPAS2, PER3, and BMAL1 appear to contribute to the risk of SAD. 17969870

2007