Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 94233
Gene Symbol: OPN4
OPN4
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.370 Biomarker PSYGENET Here we outline steps for new research to address the possible role of melanopsin in seasonal affective disorder including chromatic pupillometry designed to measure the sensitivity of melanopsin containing retinal ganglion cells. 23286902

2013

Entrez Id: 94233
Gene Symbol: OPN4
OPN4
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.370 Biomarker PSYGENET However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are symptoms of the mood disorder. 22881342

2012

Entrez Id: 94233
Gene Symbol: OPN4
OPN4
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.370 Biomarker PSYGENET Other studies reported on mRGCs in glaucoma, on genetic variation of the melanopsin gene (OPN4) in seasonal affective disorder and on the role of mRGCs in migraineous photophobia. 20691201

2011

Entrez Id: 94233
Gene Symbol: OPN4
OPN4
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.370 Biomarker PSYGENET These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. 18804284

2009