Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 AlteredExpression LHGDN In sections from AD patients we observed a clear inverse relationship between neprilysin and A beta peptide levels in the vasculature, implicating neprilysin in cerebral amyloid angiopathy. 12387451

2002
Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 GeneticVariation LHGDN Our findings suggest that the GT-repeat polymorphism in the promoter region of the NEP gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset AD. 14739539

2004
Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 AlteredExpression LHGDN We found a significant decrease in neprilysin mRNA levels in both AD and NA compared to control cases. 16226260

2005
Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 GeneticVariation LHGDN We used denaturing high-performance liquid chromatography to screen the neprilysin gene (NEP) for single nucleotide polymorphisms (SNPs) in 257 Chinese sporadic Alzheimer's disease patients and 242 cognitive normal controls. 15860464

2005
Entrez Id: 4311
Gene Symbol: MME
MME
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker LHGDN However, these novel findings add to the weight of evidence supporting the involvement of neprilysin in the aetiology of Alzheimer's disease. 17928142

2007