Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker LHGDN Lymph node metastases were present in 80% (12 out of 15) PTEN negative HCC, 57.14% (12 out of 21) PTEN weak positive HCC and only 10.71% (9 out of 84) PTEN intense positive HCC, (P<0.05). 12767263

2003

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression LHGDN Our data suggest that PTEN blocks Sp1 phosphorylation in response to HBx, by inactivating PKC, MAPK and MAPK kinase which eventually downregulate IGF-II expression, during the formation of HCC. 12804776

2003

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression LHGDN Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion. 17681183

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 AlteredExpression LHGDN The aberrant location of expression and staining intensity of PTEN, PPM1A and P-Smad2 in HCC and their relationship might have an impact on the pathogenesis of HCC. 17729405

2007

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.600 Biomarker LHGDN PTEN down-regulation or p53 (+) correlated with increased HCC dedifferentiation, advanced pathologic stages and high PCNA labeling index (LI) of tumors (P<0.05). 17982625

2007