Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.370 Biomarker PSYGENET The cyclic adenosine monophosphate-specific phosphodiesterase-4 (PDE4) gene family is the target of several potential therapeutic inhibitors and the PDE4B gene has been associated with schizophrenia and depression. 18090323

2007

Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.370 Biomarker PSYGENET Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and plays a critical role in controlling its intracellular concentration, has been implicated in depression- and anxiety-like behaviors. 17700644

2008

Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.370 Biomarker PSYGENET PDE4 has been reported to be involved in various central nervous system (CNS) functions including depression, memory, and schizophrenia, although the specific subtype mediating these effects remains unclear. 18060387

2008

Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.370 Biomarker PSYGENET The Pde4 family has been implicated in depression and cognition, and PDE4 inhibitors have been evaluated as antidepressants and possible cognitive enhancers. 22487514

2012

Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.370 Biomarker PSYGENET These data suggest that long-form PDE4Ds, at least PDE4D4 and PDE4D5, may be the promising targets for the development of PDE4 variant-selective inhibitors as the new pharmacotherapies for depressive disorders and neurodegenerative diseases involving memory deficits. 23003922

2013