Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. 22222462

2012

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET We here report analysis of data from GENDEP, a part-randomized pharmacogenomic trial, on the outcome of 811 subjects with major depression undergoing treatment with either escitalopram or nortriptyline in which the C825T SNP and three further SNPs in GNB3 were genotyped. 20826553

2011

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression. 18325652

2008

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD. 17943025

2007

Entrez Id: 2784
Gene Symbol: GNB3
GNB3
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.380 Biomarker PSYGENET Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder. 24882179

2014