Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 Biomarker RGD Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats. 19948880

2010

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 ModifyingMutation RGD Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. 15888567

2005

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.510 Biomarker RGD During GN a reduction of CLR and RAMP 2 + 3 expressions was detected on days 3, 7 and 14, while RAMP 1 rose.ADM mRNA decreased on days 3 and 7. 20431304

2010

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.510 Biomarker RGD Then, we made an anti-glomerular basement membrane (GBM) GN rat model and compared the AM expression and production in each glomeruli obtained from the control or m-PSL-treated anti-GBM GN rats. 16735801

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Therapeutic RGD Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. 11318962

2001

Entrez Id: 6346
Gene Symbol: CCL1
CCL1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 6354
Gene Symbol: CCL7
CCL7
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 1285
Gene Symbol: COL4A3
COL4A3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.340 Biomarker RGD Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis. 11158397

2001

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition. 19164508

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. 9300240

1997

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Therapeutic RGD Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture. 21718676

2011

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Biomarker RGD Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation. 27129290

2016

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Biomarker RGD Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis. 11950907

2002

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Therapeutic RGD Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis. 26999660

2016

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD The protective effect of BHR on renal function in rats with GS is possibly by way of influencing expressions of TGF-beta1, TIMP-1 and MMP1 to regulate the state of extracellular matrix and lessen the matrix aggregation. 21275176

2010

Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Therapeutic RGD Rats with progressive mesangioproliferative glomerulonephritis were treated from day 3 to day 7 after disease induction with a high-affinity oligonucleotide aptamer antagonist against platelet-derived growth factor-B chain (PDGF-B). 11316849

2001

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136

2010

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. 12495295

2002

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 ModifyingMutation RGD Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. 20720406

2010

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats. 22207560

2012

Entrez Id: 2621
Gene Symbol: GAS6
GAS6
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD In the present study, therefore, we examined in vivo roles of Gas6 and Axl in an experimental model of mesangial proliferative glomerulonephritis induced by the injection of anti-Thy1.1 antibody (Thy1 GN). 11290560

2001

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. 12675855

2003

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. 21907828

2013

Entrez Id: 2353
Gene Symbol: FOS
FOS
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Retinoid receptor-specific agonists alleviate experimental glomerulonephritis. 11880336

2002