Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Therapeutic RGD Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. 11318962

2001

Entrez Id: 2702
Gene Symbol: GJA5
GJA5
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Cx40 was detected in mesangial cells in normal rat glomeruli; its expression was reduced on days 3 and 7 and recovered to normal on day 14 following GN induction. 22945766

2013

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. 12675855

2003

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. 21907828

2013

Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Alterations in chromatin are associated with increases in collagen III expression in aging nephropathy. 20610530

2011

Entrez Id: 186
Gene Symbol: AGTR2
AGTR2
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Angiotensin II receptor blockade inhibits acute glomerular injuries with the alteration of receptor expression. 19139720

2009

Entrez Id: 5551
Gene Symbol: PRF1
PRF1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Anti-perforin antibody treatment ameliorates experimental crescentic glomerulonephritis in WKY rats. 17622272

2007

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 ModifyingMutation RGD Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. 20720406

2010

Entrez Id: 729
Gene Symbol: C6
C6
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. 10807586

2000

Entrez Id: 931
Gene Symbol: MS4A1
MS4A1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Characterization of the mononuclear cell infiltrate in the glomerulus of rats with glomerulonephritis. 7538648

1995

Entrez Id: 246
Gene Symbol: ALOX15
ALOX15
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis. 7967345

1994

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. 9300240

1997

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.510 Biomarker RGD During GN a reduction of CLR and RAMP 2 + 3 expressions was detected on days 3, 7 and 14, while RAMP 1 rose.ADM mRNA decreased on days 3 and 7. 20431304

2010

Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD During the acute phase of experimental Thy1.1 nephritis, glomerular fibrillin-1 messenger ribonucleic acid expression and protein immunoreactivity were significantly induced as compared to controls. 16395273

2006

Entrez Id: 6916
Gene Symbol: TBXAS1
TBXAS1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Effect of thromboxane A2 inhibition and antagonism on prostaglandin and leukotriene synthesis in glomerular immune injury. 10560941

1999

Entrez Id: 6346
Gene Symbol: CCL1
CCL1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 6354
Gene Symbol: CCL7
CCL7
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Therapeutic RGD Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis. 26999660

2016

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 ModifyingMutation RGD Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. 15888567

2005

Entrez Id: 1285
Gene Symbol: COL4A3
COL4A3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.340 Biomarker RGD Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis. 11158397

2001

Entrez Id: 199
Gene Symbol: AIF1
AIF1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. 17035944

2006

Entrez Id: 1524
Gene Symbol: CX3CR1
CX3CR1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. 14605272

2003

Entrez Id: 3690
Gene Symbol: ITGB3
ITGB3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. 8083378

1994

Entrez Id: 558
Gene Symbol: AXL
AXL
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. 11290560

2001

Entrez Id: 186
Gene Symbol: AGTR2
AGTR2
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Biomarker RGD Glomerulosclerosis was assessed by renal biopsy 8 wk later, and rats were divided into four groups with equivalent glomerulosclerosis: no further treatment, ARB, AT2 receptor antagonist, or combination. 20042458

2010