Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5726
Gene Symbol: TAS2R38
TAS2R38
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.540 Biomarker PSYGENET These results are inconsistent with the view that excessive use of alcohol causes the association between nontasting and alcoholism and are consistent with the view that there is a genetic association between PROP/PTC-tasting and alcoholism. 1641428

1992

Entrez Id: 2688
Gene Symbol: GH1
GH1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker PSYGENET The investigation compared 37 men who were family history positive for alcoholism with 37 family history negative controls on postinfusion levels of cortisol, prolactin, and growth hormone following 0.12 and 0.20 mg/kg of diazepam given IV over 7 minutes. 1877741

1991

Entrez Id: 26503
Gene Symbol: SLC17A5
SLC17A5
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.310 Biomarker PSYGENET In an attempt to explain the well-known increase of serum mitochondrial AST-to-total AST ratio in chronic alcoholism (which is due to a specific increase of the mitochondrial isoenzyme), we analyzed: (a) liver and serum AST, ALT and glutamate dehydrogenase activities in 23 active drinkers with minimal liver changes, 11 alcoholic patients with cirrhosis who had stopped drinking, 18 nonalcoholic patients with viral chronic hepatitis and 11 subjects with normal livers; and (b) the expression of messenger RNAs for AST isoenzymes in the corresponding liver samples. 1916663

1991

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.300 Biomarker PSYGENET These findings suggest that genetically mediated alterations in the renin gene may exert a significant influence on alcohol consumption and may be a component in the etiology of alcoholism. 2024728

1991

Entrez Id: 28
Gene Symbol: ABO
ABO
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.320 Biomarker PSYGENET We conclude that, although alcoholism is a factor in the development of osteopenia, in males the ABO blood group status plays a significant role in the maximal mineralization of the skeleton and the amount of bone resorption during ageing, independent of alcohol abuse. 2088127

1990

Entrez Id: 7200
Gene Symbol: TRH
TRH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker PSYGENET The results of the TRH test and the DST point to similar endocrinological patterns in alcoholics as in depressive patients and thus support the hypothesis of a link between alcoholism and depression. 2543997

1989

Entrez Id: 28
Gene Symbol: ABO
ABO
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.320 Biomarker PSYGENET Linkage was investigated between a putative alcoholism susceptibility (AS) gene and six blood group markers: ABO, Rhesus, Duffy, Kidd, Kell, and MNS. 3146230

1988

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker PSYGENET The test-retest reliability for the age of onset of major depression and panic disorder was excellent, and for phobia, GAD and alcoholism, was acceptable. 3261342

1988

Entrez Id: 7086
Gene Symbol: TKT
TKT
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.320 Biomarker PSYGENET This study was undertaken to delineate whether transketolase abnormality (i.e., high Michaelis Menton constant (Km) for thiamine pyrophosphate), previously reported in patients with Wernicke-Korsakoff syndrome is prevalent among familial chronic alcoholic men and their sons without prior history of alcohol abuse but who are at high risk for alcoholism. 3558815

1987

Entrez Id: 410
Gene Symbol: ARSA
ARSA
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker PSYGENET There is a relatively high occurrence of the arylsulfatase A variants in patients with alcoholism. 6146271

1984

Entrez Id: 7200
Gene Symbol: TRH
TRH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker PSYGENET Various types of phenotypic markers are discussed and alcoholism is taken as a model for a more detailed discussion of available putative phenotypic markers and of research strategies to be used, namely the pharmacological challenge in high risk subjects (e.g. ethanol and TRH challenge). 6439854

1984

Entrez Id: 6462
Gene Symbol: SHBG
SHBG
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.510 Biomarker PSYGENET Sex hormone binding globulin phenotypes: their detection and distribution in healthy adults and in different clinical conditions. 8088001

1994

Entrez Id: 2033
Gene Symbol: EP300
EP300
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.300 Biomarker PSYGENET For example, early efforts to study, in families, the co-occurrence of the P300 marker and alcoholism have yielded results indicating that the P300 abnormality precedes significant exposure to alcohol and that relatives of alcoholics are more likely to have this trait. 8234925

1993

Entrez Id: 7200
Gene Symbol: TRH
TRH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker PSYGENET The thyrotropin releasing hormone stimulation test in alcoholism. 8554651

1995

Entrez Id: 7200
Gene Symbol: TRH
TRH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.350 Biomarker PSYGENET Thyrotropin and prolactin responses to thyrotropin-releasing hormone in young men at high or low risk for alcoholism. 8561281

1995

Entrez Id: 410
Gene Symbol: ARSA
ARSA
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker PSYGENET Association of alcoholism with the N-glycosylation polymorphism of pseudodeficient human arylsulfatase A. 8730212

1996

Entrez Id: 410
Gene Symbol: ARSA
ARSA
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.330 Biomarker PSYGENET Structural characterization of variant forms of arylsulfatase A that associate with alcoholism. 8730213

1996

Entrez Id: 7054
Gene Symbol: TH
TH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.360 Biomarker PSYGENET Results suggest that no major influence on alcoholism is exerted through genes associated with the DRD4 or TH allelic markers examined. 9046370

1997

Entrez Id: 7054
Gene Symbol: TH
TH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.360 Biomarker PSYGENET Eighty-one probands with MDD, 113 probands with alcoholism, and 80 normal controls were tested for differences in frequency of nine haplotypes at the TH locus. 9184313

1997

Entrez Id: 7166
Gene Symbol: TPH1
TPH1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.360 Biomarker PSYGENET The intron 7 variant in the TPH gene showed significant evidence for linkage to suicidality (P=.006 in unaffected sib pairs), severe suicide attempts (P=.006 in unaffected sib pairs; regression: P=.01), alcoholism (P=.003 in unaffected sib-pairs; regression: P=.02), and Karolinska Scales of Personality socialization score (regression: P=.002). 9672049

1998

Entrez Id: 1080
Gene Symbol: CFTR
CFTR
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.300 Biomarker PSYGENET Eighteen patients (13.4 percent), including 12 without alcoholism, had a CFTR mutation on one chromosome, as compared with a frequency of 5.3 percent among 600 local unrelated partners of persons with a family history of cystic fibrosis (P<0.001). 9725921

1998

Entrez Id: 7054
Gene Symbol: TH
TH
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.360 Biomarker PSYGENET Our study indicates that the TH gene is not likely to play a major role in the genetic predisposition to schizophrenia, mood disorders, or alcohol dependence. 9754624

1998

Entrez Id: 2562
Gene Symbol: GABRB3
GABRB3
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.340 Biomarker PSYGENET However, when the DRD2 and the GABRB3 variants are combined, the risk for alcoholism is more robust than when these variants are considered separately. 9858031

1998

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.360 Biomarker PSYGENET There was no evidence that two polymorphisms of the 5-HT2A receptor gene and one of the 5-HT2C receptor gene were related to LR or alcoholism in this sample. 10088053

1999

Entrez Id: 2559
Gene Symbol: GABRA6
GABRA6
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.340 Biomarker PSYGENET Taking into account the high a priori risk of false-positive association findings due to multiple testing, further replication studies are necessary to examine the tentative phenotype-genotype relationship of GABRA6 gene variants and dissocial alcoholism. 10195814

1999