Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN Our results suggest that IFN-alpha could sensitize certain human hepatoma cells to TRAIL-induced apoptosis by stimulating its death signaling and by repressing the survival function in these cells. 12642868

2003

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN The TRAIL on HCC cells induced apoptosis in Jurkat cells that are sensitive to TRAIL-mediated apoptosis, and this process was specifically inhibited by recombinant TRAIL-receptors:Fc which binds to TRAIL. 15809718

2005

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 Biomarker LHGDN We show that TRAIL is upregulated in hepatoma cells upon treatment with TGF-beta, whereas TRAIL receptor levels remain unchanged. 15962328

2005

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN A tumor-specific conditionally replicative adenovirus vector expressing TRAIL for gene therapy of hepatocellular carcinoma. 16082383

2006

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN The combined delivery of Ad/hTERT-CYLD and ZD55-TRAIL may be a new useful strategy for HCC or other tumor cells with enhanced NF-kappaB activity. 16627981

2006

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.400 AlteredExpression LHGDN Our results reveal a new AP-1 site within the TRAIL promoter functionally involved in TGF-beta-induced TRAIL expression and apoptosis in hepatomas and thus provide evidence for the underlying mechanism by which TGF-beta might regulate cell death in liver cancer. 18644981

2008