Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders. 21835597

2011

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET Several circadian genes have been found to be associated with bipolar disorders: at least three studies have reported positive associations for each of CLOCK, NPAS2, ARNTL1, NR1D1, PER3, RORB and CSNK1epsilon. 24389266

2014

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET Using lymphoblastoid cell lines from patients with BD, we found that both the NR1D1 and GSK3β variants are associated with functional differences in gene expression. 21781277

2011

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.330 Biomarker PSYGENET We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. 20072116

2010

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.320 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.320 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.320 Biomarker PSYGENET Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders. 21835597

2011