Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. 16314880

2006

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.510 Biomarker PSYGENET Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. 16272961

2005

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Although platelet 5-HTT densities are reduced in patients with cocaine dependence compared with healthy volunteers, these genotypic variations in the serotonin transporter do not seem to influence levels of platelet 5-HTT in cocaine-dependent patients or healthy volunteers. 15091312

2004

Entrez Id: 6571
Gene Symbol: SLC18A2
SLC18A2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Bakuchiol analogs, especially Delta3,2-hydroxybakuchiol, are monoamine transporter inhibitors involved in regulating dopaminergic and noradrenergic neurotransmission and may have represented potential pharmacotherapies for disorders such as Parkinson's disease, depression, and cocaine addiction. 18329002

2008

Entrez Id: 1814
Gene Symbol: DRD3
DRD3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. 12847556

2003

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.540 Biomarker PSYGENET Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. 16184603

2005

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction. 20133874

2010

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker PSYGENET DBH gene as predictor of response in a cocaine vaccine clinical trial. 23458673

2013

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Disulfiram and methylphenidate pharmacotherapies for cocaine addiction are optimized by considering polymorphisms affecting DbetaH and DAT1 respectively. 19462300

2009

Entrez Id: 4985
Gene Symbol: OPRD1
OPRD1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). 17622222

2008

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Evidence suggests that the kappa-opioid receptor (KOP-r) system plays an important role in cocaine addiction. 17532787

2007

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Findings from these studies have led us to recognize the profound disruption of both dynorphin gene expression and kappa opioid receptor gene expression in a setting of chronic cocaine administration and, in turn, have led us to question a possible role of disruption of this system in the acquisition and persistence of cocaine addiction. 8943583

1996

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET For African Americans, we find decreased cocaine dependence symptoms among carriers of missense variants in CHRNA3 (FamSKAT P = 0.005). 24057674

2014

Entrez Id: 1142
Gene Symbol: CHRNB3
CHRNB3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3. 24057674

2014

Entrez Id: 5173
Gene Symbol: PDYN
PDYN
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.540 Biomarker PSYGENET Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction. 22443215

2012

Entrez Id: 2555
Gene Symbol: GABRA2
GABRA2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391

2013

Entrez Id: 4988
Gene Symbol: OPRM1
OPRM1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391

2013

Entrez Id: 9679
Gene Symbol: FAM53B
FAM53B
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.420 Biomarker PSYGENET Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. 23958962

2014

Entrez Id: 4986
Gene Symbol: OPRK1
OPRK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.550 Biomarker PSYGENET Here, we examined whether the OPRK1 rs6989250 C>G affects stress-induced cocaine craving and cortisol responses, subsequent cocaine relapse risk and the neural response to stress using functional magnetic resonance imaging (fMRI) in cocaine dependence. 23962922

2013

Entrez Id: 8864
Gene Symbol: PER2
PER2
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. 17106427

2006

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET In the FSCD, there was a significant association between the CHRNA5 variant and cocaine dependence (odds ratio = .67 per allele, p = .0045, assuming an additive genetic model), but in the reverse direction compared with that previously observed for nicotine dependence. 18519132

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET In this issue of Neuropsychopharmacology, several studies are presented supporting a role for COMT as a factor in cocaine addiction, brain reward activation, response to tolcapone, distractibility in ADHD, and fMRI bold response. 18923401

2008

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET In this study, we attempt to replicate findings associating CNR1 with CD in African Americans. 21790903

2013

Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.600 Biomarker PSYGENET Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. 21150910

2011