Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 148
Gene Symbol: ADRA1A
ADRA1A
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET This study indicates that a patient's ADRA1A genotype could be used to identify a subset of individuals for which disulfiram and, perhaps, other α1-adrenoceptor blockers may be an effective pharmacotherapy for cocaine dependence. 23849431

2013

Entrez Id: 255239
Gene Symbol: ANKK1
ANKK1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram. 23635803

2013

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our findings propose a new role for AVP in cocaine addiction. 19596360

2010

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET Our studies indicate that the AVP and its V1b receptor system may be a potential therapeutic target for treating anxiety and depressive symptoms associated with cocaine addiction. 21677651

2011

Entrez Id: 814
Gene Symbol: CAMK4
CAMK4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.510 Biomarker PSYGENET We found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regions did not correlate with drug abuse. 19001277

2008

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET These results support the idea that Cdk5 activity is involved in altered gene expression after chronic exposure to cocaine and hence impacts the long-lasting changes in neuronal function underlying cocaine addiction. 15665076

2005

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Our results suggest that changes in Cdk5 levels mediated by DeltaFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction. 11268215

2001

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET For African Americans, we find decreased cocaine dependence symptoms among carriers of missense variants in CHRNA3 (FamSKAT P = 0.005). 24057674

2014

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET In the FSCD, there was a significant association between the CHRNA5 variant and cocaine dependence (odds ratio = .67 per allele, p = .0045, assuming an additive genetic model), but in the reverse direction compared with that previously observed for nicotine dependence. 18519132

2008

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014

Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.330 Biomarker PSYGENET The strongest association signal in either sample was between rs684513 in CHRNA5 and cocaine dependence (OR=1.43, P=0.0004) in the AA replication set. 20485328

2010

Entrez Id: 1142
Gene Symbol: CHRNB3
CHRNB3
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.320 Biomarker PSYGENET For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3. 24057674

2014

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET We applied this method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-American samples. 18759969

2008

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.300 Biomarker PSYGENET To investigate the possible contribution of rare variants to the development of substance dependencies other than nicotine dependence, specifically alcohol and cocaine dependence, we undertook pooled sequencing of the coding regions and flanking sequence of CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3 in 287 African American and 1028 European American individuals from the Collaborative Study of the Genetics of Alcoholism (COGA). 24057674

2014

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Biomarker PSYGENET Variants in the CLOCK gene were significantly associated with the heavy cocaine use, infrequent intravenous injection group, but not with the DSM-IV diagnosis of CD. 24339190

2014

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET The interaction between two independent CNR1 variants, ie, the G allele-containing genotypes of rs6454674 (SNP3(G+)), and the T/T genotype of rs806368 (SNP8(T)/T), significantly increased risk for CD in the EA family (P(GEE)=0.015) and EA case-control (P(regression)=0.003) samples. 19052543

2009

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. 16314880

2006

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.530 Biomarker PSYGENET In this study, we attempt to replicate findings associating CNR1 with CD in African Americans. 21790903

2013

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET In this issue of Neuropsychopharmacology, several studies are presented supporting a role for COMT as a factor in cocaine addiction, brain reward activation, response to tolcapone, distractibility in ADHD, and fMRI bold response. 18923401

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET Results suggest that variation in COMT increases risk for cocaine dependence. 18704099

2008

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.520 Biomarker PSYGENET Several studies have looked for a link between cocaine addiction and the genes of the dopaminergic system: the genes DRD2, COMT, SLC6A3 (coding for the dopamine transporter DAT) and DBH (coding for the dopamine beta hydroxylase) but unfortunately very few well established results. 20801583

2010

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.510 Biomarker PSYGENET We found that a single nucleotide polymorphism in the CAMK4 promoter was significantly associated with cocaine addiction, whereas variations in the CREB promoter regions did not correlate with drug abuse. 19001277

2008

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.390 Biomarker PSYGENET This study indicates that the DBH genotype of a patient could be used to identify a subset of individuals for which disulfiram treatment might be an effective pharmacotherapy for cocaine dependence. 22906516

2013