Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Transcriptomics of post-stroke angiogenesis in the aged brain. 24672479

2014

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Enalapril attenuates ischaemic brain oedema and protects the blood-brain barrier in rats via an anti-oxidant action. 24471927

2014

Entrez Id: 7122
Gene Symbol: CLDN5
CLDN5
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats. 24211797

2014

Entrez Id: 2475
Gene Symbol: MTOR
MTOR
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. 24583056

2014

Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro. 25069640

2014

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-κB, MMP-9 and up-regulated claudin-5 expression. 24842554

2014

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2. 23880501

2013

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. 24466583

2013

Entrez Id: 56963
Gene Symbol: RGMA
RGMA
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. 23275173

2013

Entrez Id: 10014
Gene Symbol: HDAC5
HDAC5
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850

2013

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2013

Entrez Id: 6608
Gene Symbol: SMO
SMO
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke. 23696546

2013

Entrez Id: 1965
Gene Symbol: EIF2S1
EIF2S1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. 23669639

2013

Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. 23516428

2013

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. 23600725

2013

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850

2013

Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. 24012531

2013

Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850

2013

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. 23870531

2013

Entrez Id: 9734
Gene Symbol: HDAC9
HDAC9
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. 23480850

2013

Entrez Id: 6608
Gene Symbol: SMO
SMO
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. 23499832

2013

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Biomarker RGD The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. 24090950

2013

Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. 23149556

2013

Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.200 Therapeutic RGD Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-α levels, and IL-10 mRNA, TNF-α mRNA expression levels, cerebral TGF-β1 positive expression level and its neuroprotective mechanisms in CIR rats. 23378241

2013