Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6648
Gene Symbol: SOD2
SOD2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Biomarker RGD Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction. 14575298

2003

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.520 Therapeutic RGD Myocardial autophagy variation during acute myocardial infarction in rats: the effects of carvedilol. 20079142

2009

Entrez Id: 5350
Gene Symbol: PLN
PLN
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.510 Therapeutic RGD Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction. 23781262

2013

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.510 Biomarker RGD These data suggest that the need for an increasing TGFβ₁ bioavailability during the post-infarction period in rat myocardium is achieved in the early post MI period by an increased expression of uPA/uPAR proteolytic system (indirect activation of latent TGFβ₁) and in the late post MI period by direct regulation of TGFβ₁ expression. 20952728

2011

Entrez Id: 598
Gene Symbol: BCL2L1
BCL2L1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.500 Biomarker RGD Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion. 17467744

2007

Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.500 Biomarker RGD Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts. 17587755

2007

Entrez Id: 4625
Gene Symbol: MYH7
MYH7
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.500 Biomarker RGD Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. 15090263

2004

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker RGD The rats in the intervention groups were injected with SDF-1, anti-SDF-1 antibody or saline 4 days after myocardial infarction. 19187644

2009

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.400 Biomarker RGD In order to study SDF-1 expression in a rat model of myocardial infarction, we cloned and functionally expressed the rat SDF-1alpha orthologue. 11820456

2001

Entrez Id: 3717
Gene Symbol: JAK2
JAK2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.340 SusceptibilityMutation RGD Emulsified isoflurane induces postconditioning against myocardial infarction via JAK-STAT pathway. 22749532

2012

Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.320 Biomarker RGD Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. 12123772

2002

Entrez Id: 3920
Gene Symbol: LAMP2
LAMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.310 Biomarker RGD The key findings of the present study were: a) upregulation of autophagy-related genes (GABARAPL1, ATG7, BNIP3, CTSL1 and LAMP2) was observed only in plantaris while muscle atrophy was observed in both soleus and plantaris muscles, and b) Cathepsin L activity, Bnip3 and Fis1 protein levels, and levels of lipid hydroperoxides were increased specifically in plantaris muscle of MI rats. 24427319

2014

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction. 12400771

2002

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Therapeutic RGD MI also significantly increased ACE and angiotensin type 1 receptor levels but decreased ACE2 activity by 40% (control, 246.2±25.1; DIZE alone, 254.2±20.6; MI, 148.9±29.2; RFU/min), which was reversed by DIZE treatment. 23959549

2013

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. 15247145

2004

Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Thus, myocardial ischemia induced by left coronary artery ligation resulted in a sustained increase in Ang-2 expression and a reciprocal decrease in Ang-1, consistent with a predominant role for Ang-2 in the angiogenic response to MI. 15364619

2004

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. 16053971

2005

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Therapeutic RGD In post-MI heart failure, ARB attenuated MCP-1 expression and macrophage infiltration in the border zone, resulting in less myocardial fibrosis. 18753699

2008

Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. 20089851

2010

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model. 19858735

2010

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Therapeutic RGD Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. 29428663

2018

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Increased susceptibility to ischemia-induced ventricular tachyarrhythmias in depressed rats: Involvement of reduction of connexin 43. 22969867

2012

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. 11179039

2001

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD We investigated the expression pattern of IGF-1 gene transcripts in rat myocardium from 1 h up to 8 wks after myocardial infarction induced by left anterior descending coronary artery ligation. 19295919

2009

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. 9652322

1998