Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6590
Gene Symbol: SLPI
SLPI
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction. 23361363

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction. 16845718

2006

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Therapeutic RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 59272
Gene Symbol: ACE2
ACE2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD By day 28, increases in ACE (P = 0.005) and ACE2 (P = 0.006) mRNA were also seen in the viable myocardium of MI rats compared with myocardium of control rats. 15671045

2005

Entrez Id: 3570
Gene Symbol: IL6R
IL6R
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.320 Biomarker RGD Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. 12123772

2002

Entrez Id: 3675
Gene Symbol: ITGA3
ITGA3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling. 19041328

2009

Entrez Id: 2539
Gene Symbol: G6PD
G6PD
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Therapeutic RGD Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. 20462747

2011

Entrez Id: 859
Gene Symbol: CAV3
CAV3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. 12566108

2003

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.240 Biomarker RGD CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. 18954648

2008

Entrez Id: 1232
Gene Symbol: CCR3
CCR3
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair. 18954648

2008

Entrez Id: 1584
Gene Symbol: CYP11B1
CYP11B1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. 18689429

2009

Entrez Id: 1601
Gene Symbol: DAB2
DAB2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction. 20666606

2011

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 ModifyingMutation RGD Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention. 21326342

2011

Entrez Id: 2335
Gene Symbol: FN1
FN1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.260 Biomarker RGD Compared with vehicle-treated MI rats, oral valsartan, but not PD123319, limited infarct size, normalized MMPs/TIMP-1 balance and restored FN level. 19695229

2009

Entrez Id: 1490
Gene Symbol: CCN2
CCN2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation. 18167060

2008

Entrez Id: 5764
Gene Symbol: PTN
PTN
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Conversely, we show in a rat model of myocardial infarction and in human dilated cardiomyopathy that pleiotrophin is markedly up-regulated. 17925408

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.360 Biomarker CTD_mouse Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. 24358288

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. 23143013

2013

Entrez Id: 4625
Gene Symbol: MYH7
MYH7
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.500 Biomarker RGD Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. 15090263

2004

Entrez Id: 4624
Gene Symbol: MYH6
MYH6
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. 15090263

2004

Entrez Id: 1457
Gene Symbol: CSNK2A1
CSNK2A1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. 15090263

2004

Entrez Id: 1460
Gene Symbol: CSNK2B
CSNK2B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Differential gene expression in infarct scar and viable myocardium from rat heart following coronary ligation. 15090263

2004

Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.200 Biomarker RGD Disparate regulation of signaling proteins after exercise and myocardial infarction. 16540832

2006

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.300 Biomarker RGD Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. 16053971

2005

Entrez Id: 4191
Gene Symbol: MDH2
MDH2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.210 Biomarker RGD Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats. 9753871

1998