Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9572
Gene Symbol: NR1D1
NR1D1
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.320 Biomarker PSYGENET Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders. 21835597

2011

Entrez Id: 8863
Gene Symbol: PER3
PER3
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.320 Biomarker PSYGENET Certain allelic combinations of NPAS2, PER3, and BMAL1 appear to contribute to the risk of SAD. 17969870

2007

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET We have genotyped 82 SAD patients and 82 healthy controls from Sweden, Finland, and Germany for this and five other polymorphisms in the genes coding for serotonin receptors 5-HT2A and 5-HT2C, tryptophan hydroxylase and white. 11300730

2001

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 1408
Gene Symbol: CRY2
CRY2
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The role of circadian clock genes in mental disorders. 17969870

2007

Entrez Id: 1407
Gene Symbol: CRY1
CRY1
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET (1) A subgroup of depressed patients have documented circadian abnormalities in mood, sleep, temperature and neuroendocrine secretion; (2) It is also suggested that seasonal affective disorder (SAD) patients may show an abnormality in their ability to shift their daily circadian rhythms in response to seasonal light changes; (3) The dramatic improvements in some depressions in response to three treatment modalities which manipulate circadian rhythms suggest that circadian abnormalities reported in patients may constitute a core component of the pathophysiology in depression; (4) Mutations in clock genes have been discovered that accelerate or delay circadian cycles; (5) It is hypothesized that 24-hour rhythm abnormalities in major depression and SAD may be due to altered clock genes. 10700653

2000

Entrez Id: 3358
Gene Symbol: HTR2C
HTR2C
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. 16157158

2005

Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. 21565467

2012

Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET Genetics of circadian rhythms and mood spectrum disorders. 21835597

2011

Entrez Id: 5141
Gene Symbol: PDE4A
PDE4A
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.300 Biomarker PSYGENET Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice. 18245171

2008

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.300 Biomarker PSYGENET Among some SAD patients, it is possible that the sustained ingestion of high-fat diet will rather activate the transcription of the neuropeptide Y gene than deactivate it, indicating a defect in macronutrient selection. 8898322

1996