×
Entrez Id: 3643
Gene Symbol: INSR
INSR
Alzheimer's Disease
0.600
Biomarker
RGD
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
16627931 2006
INS-IGF2
Alzheimer's Disease
0.210
Biomarker
RGD
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.
17448147 2007
×
Entrez Id: 3630
Gene Symbol: INS
INS
Alzheimer's Disease
0.530
Biomarker
RGD
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.
17448147 2007
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Alzheimer's Disease
0.400
Therapeutic
RGD
The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine.
27088818 2016
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Alzheimer's Disease
0.600
Biomarker
RGD
Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway.
22963993 2012
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Alzheimer's Disease
0.600
Therapeutic
RGD
Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease.
23378761 2013
×
Entrez Id: 3551
Gene Symbol: IKBKB
IKBKB
Alzheimer's Disease
0.220
Therapeutic
RGD
Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42.
24380241 2013
×
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
Alzheimer's Disease
0.570
Biomarker
RGD
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
16627931 2006
×
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
Alzheimer's Disease
0.560
Biomarker
RGD
While these disturbances were mostly corrected by restoring receptor function, blockade of the IGF-I receptor exacerbated AD -like pathology in old mutant mice already affected of brain amyloidosis and cognitive derangement.
16274856 2006
×
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
Alzheimer's Disease
0.560
Therapeutic
RGD
Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats.
23562514 2013
×
Entrez Id: 3416
Gene Symbol: IDE
IDE
Alzheimer's Disease
0.600
Therapeutic
RGD
Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.
28157092 2017
×
Entrez Id: 3416
Gene Symbol: IDE
IDE
Alzheimer's Disease
0.600
Therapeutic
RGD
Neuroprotective mechanism of
28553348 2017
×
Entrez Id: 3416
Gene Symbol: IDE
IDE
Alzheimer's Disease
0.600
Therapeutic
RGD
Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation.
28447730 2017
×
Entrez Id: 3416
Gene Symbol: IDE
IDE
Alzheimer's Disease
0.600
Therapeutic
RGD
Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels.
29948724 2018
×
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
Alzheimer's Disease
0.240
Biomarker
RGD
Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease.
15802185 2005
×
Entrez Id: 3315
Gene Symbol: HSPB1
HSPB1
Alzheimer's Disease
0.230
Biomarker
RGD
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
25772164 2015
×
Entrez Id: 3297
Gene Symbol: HSF1
HSF1
Alzheimer's Disease
0.250
Biomarker
RGD
Even more interesting, injection of lentivirus vector-HSF1 into the cerebella of AD rats significantly increased HSF1 and HSP expression levels and induced an increase in the number of Purkinje cell bodies.
23665061 2013
×
Entrez Id: 2936
Gene Symbol: GSR
GSR
Alzheimer's Disease
0.240
Therapeutic
RGD
Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type.
19374888 2009
×
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
Alzheimer's Disease
0.700
Therapeutic
RGD
Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease.
29257340 2018
×
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
Alzheimer's Disease
0.700
Biomarker
RGD
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
22982863 2012
×
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
Alzheimer's Disease
0.700
Therapeutic
RGD
Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway.
27893738 2016
×
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
Alzheimer's Disease
0.300
Biomarker
RGD
Therefore, we studied the specific activity of GAPDH in the different animal models of AD : transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and interferon gamma (INFgamma).
17324518 2007
×
Entrez Id: 1759
Gene Symbol: DNM1
DNM1
Alzheimer's Disease
0.260
Biomarker
RGD
Significant decreases in protein levels of dynamin I , AP180, and synaptophysin were observed in both AD patients and mice with AβPPSWE as compared to controls.
20847448 2010
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Alzheimer's Disease
0.300
Therapeutic
RGD
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils.
12610652 2003
×
Entrez Id: 10519
Gene Symbol: CIB1
CIB1
Alzheimer's Disease
0.230
Biomarker
RGD
In AD brain a substantial loss of Calmyrin -immunopositive neurones was observed in all regions, especially in cortical areas.
15885068 2005