DisGeNET - a database of gene-disease associations

Source: ANIMAL_MODELS

Disease: Chronic kidney disease stage 5 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	8678
Gene Symbol:	BECN1

BECN1

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.

24090408

2013

Entrez Id:	4036
Gene Symbol:	LRP2

LRP2

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Modulation of gene expression by moxonidine in rats with chronic renal failure.

15266031

2004

Entrez Id:	5228
Gene Symbol:	PGF

PGF

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model.

16543713

2006

Entrez Id:	5970
Gene Symbol:	RELA

RELA

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.

18077597

2008

Entrez Id:	1543
Gene Symbol:	CYP1A1

CYP1A1

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Downregulation of intestinal cytochrome p450 in chronic renal failure.

12039987

2002

Entrez Id:	4973
Gene Symbol:	OLR1

OLR1

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

These results suggest that enhanced renal expression of LOX-1 might play some roles in the progression of chronic renal failure in rats.

12661921

2003

Entrez Id:	9817
Gene Symbol:	KEAP1

KEAP1

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.

20007347

2010

Entrez Id:	10631
Gene Symbol:	POSTN

POSTN

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells.

22167593

2012

Entrez Id:	6721
Gene Symbol:	SREBF2

SREBF2

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Increased gene expression of liver SREBP-2 in experimental chronic renal failure.

16814791

2007

Entrez Id:	23560
Gene Symbol:	GTPBP4

GTPBP4

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Identification of a novel nuclear guanosine triphosphate-binding protein differentially expressed in renal disease.

11316846

2001

Entrez Id:	3990
Gene Symbol:	LIPC

LIPC

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone.

8636395

1996

Entrez Id:	3156
Gene Symbol:	HMGCR

HMGCR

CUI:	C2316810
Disease:	Chronic kidney disease stage 5

Chronic kidney disease stage 5

0.200

Biomarker

RGD

Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.

21119529

2011