Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker RGD Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in Aβ1-42 CA1-injected rats. 30066400

2019

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker RGD Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats. 29174383

2018

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Therapeutic RGD Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats. 29568075

2018

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker RGD In this study, we explore the effects of altered angiotensin-converting enzyme (ACE), and investigate the possible mechanisms of perindopril, an ACE inhibitor, on brain structure and function in a rat model of AD, as well as the role that ACE plays in AD. 19080340

2008

Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 Biomarker MGD

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. 29257340

2018

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. 29126976

2018

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model. 28342971

2017

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Antioxidative and Neuroprotective Effects of Curcumin in an Alzheimer's Disease Rat Model Co-Treated with Intracerebroventricular Streptozotocin and Subcutaneous D-Galactose. 27060945

2016

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway. 27893738

2016

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. 24792732

2014

Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. 23296102

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD These results are consistent with a role for APOE in Aβ clearance in AD synapses, and suggest that optimal lipidation of apoE2 compared to E3 and E4 makes an important contribution to Aβ clearance and synaptic function. 22020632

2012

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker RGD Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. 22982863

2012

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Therapeutic RGD Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. 20088507

2010

Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker MGD

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.680 Biomarker MGD

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. 29777699

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model. 29587274

2018

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. 29948724

2018

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ 29642617

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Neuroprotective Effect of Nanodiamond in Alzheimer's Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling. 26897372

2017

Entrez Id: 3416
Gene Symbol: IDE
IDE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease. 28157092

2017