Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN Immunohistochemistry was used to measure collagen III deposition and TGF-beta(1) expression in biopsies from patients with long-standing asthma treated with inhaled corticosteroids, patients with recently diagnosed asthma, and control subjects. 19043669

2009

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN Hence, IL-13 may contribute to subepithelial fibrosis in asthma by stimulating biologically significant TGF-beta2 secretion from the airway epithelium. 18348727

2008

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN Combined analysis revealed that atopic asthmatic children co-inherited the risk alleles of TNF-alpha-308G/A and IL-13 +2044G/A more frequently than control children (aOR 1.91, 95% CI 1.00-3.65), and asthmatic children co-inheriting both risk alleles had significantly lower PC(20) values vs. asthmatic children homozygous for the common alleles (P=0.024). 18341619

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1. 18802103

2008

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma. 18712274

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis. 18359288

2008

Entrez Id: 30009
Gene Symbol: TBX21
TBX21
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN An association between a specific TBX21 haplotype and allergic asthma in children is demonstrated for the first time and might explain previously detected associations between SNPs within TBX21 and asthma and bronchial hyperresponsiveness. 17949803

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City. 17333284

2007

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN This augmentation of TGF-beta1-induced TIMP-1 by IL-13 could contribute to the fibrosis and airway remodeling seen in the presence of T(H)2 inflammation in asthma. 17418380

2007

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures. 17673695

2007

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. 17845580

2007

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN Most interestingly, for the first time, a highly significant association of the newly studied (GAAGGA)(n) hexanucleotide repeat with asthma (p = 3x10(-6)), log(10)TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed. 17220216

2007

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN This is the first report to suggest a functional role for Nox4 in cell cycle transition and to demonstrate that Nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote TGF-beta1-induced proliferation and hypertrophy of human airway smooth muscle. 17369289

2007

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN Expression of IL-13 gene in 70% of patients with allergic asthma was higher than controls (P=0.01). 17563406

2007

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production. 17006604

2006

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. 16461126

2006

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma. 16690986

2006

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN CCL11 SNPs and haplotypes were not associated with asthma among white or Hispanic families. 16461130

2006

Entrez Id: 30009
Gene Symbol: TBX21
TBX21
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. 16179640

2006

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. 16001979

2005

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN African American asthmatics/atopics had higher frequency of the TT mutant gene for the -1055 IL-13 SNP and of its mutant T allele. 16024972

2005

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker LHGDN The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells. 15661077

2005

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics. 16001979

2005

Entrez Id: 30009
Gene Symbol: TBX21
TBX21
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation LHGDN In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects. 15806396

2005

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression LHGDN Our results suggest that the polymorphisms of the eotaxin gene family are associated with the susceptibility of asthma and Eotaxin-3 might play the critical role for the recruitment of eosinophils and the maintenance of IgE levels. 15207712

2004