Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 Biomarker MGD Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. 12606498

2003
Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.960 Biomarker MGD Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). 11387480

2001
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 Biomarker MGD Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. 9566924

1998
Entrez Id: 2645
Gene Symbol: GCK
GCK
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 Biomarker MGD Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. 8530440

1995
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 Biomarker MGD Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. 7969452

1994
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 Biomarker MGD Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene. 9312184

1997
Entrez Id: 6517
Gene Symbol: SLC2A4
SLC2A4
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 Biomarker MGD The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity. 9334720

1997
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. 18288891

2008
Entrez Id: 3630
Gene Symbol: INS
INS
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. 17911348

2007
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2(-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition. 15685168

2005
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Loss of Hmga1 expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major targets of insulin action, largely impaired insulin signaling and severely reduced insulin secretion, causing a phenotype characteristic of human type 2 diabetes. 15924147

2005
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD It has been reported that insulin receptor substrate (IRS)-1 deficient (IRS-1-/-) mice showed insulin resistance without type 2 diabetes, whereas the IRS-2 deficient (IRS-2-/-) mice showed insulin resistance with type 2 diabetes. 12810606

2003
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates peripheral insulin action and pancreatic beta cell function, so mice lacking Irs2 display similarities to humans with type 2 diabetes. 14617753

2003
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. 11812758

2002
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. 11259600

2001
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD IRS-2 pathways integrate female reproduction and energy homeostasis. 11014193

2000
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Although homozygous IRS-2-deficient mice (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. 11078455

2000
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes. 9495343

1998
Entrez Id: 6514
Gene Symbol: SLC2A2
SLC2A2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. 9354799

1997
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 Biomarker MGD

Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 29551634

2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development. 26441241

2015
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. 24332968

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD To determine the role of glucagon action in diet-induced and genetic type 2 diabetes (T2D), we studied high-fat-diet-induced obese (DIO) and leptin receptor-defective (LepR(-/-)) rodents with and without glucagon receptors (GcgRs). 25157166

2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 Biomarker MGD Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis. 22609345

2012