×
Entrez Id:
9370
Gene Symbol:
ADIPOQ
ADIPOQ
Kidney Failure, Chronic
0.600
Biomarker
RGD
Changes of adiponectin and its receptors in rats following chronic renal failure.
24028144
2014
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
Kidney Failure, Chronic
0.600
Therapeutic
RGD
Sedentary CRF rats exhibited azotemia, hypertension, anemia, oxidative stress, activation of NF-kappaB and upregulations of reactive oxygen species-generating enzyme, NAD(P)H oxidase, MCP-1 , cyclooxygenase-2 (COX-2), and PAI-1 in LV.
18797164
2009
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
Kidney Failure, Chronic
0.600
Therapeutic
RGD
Although compelling evidence of a beneficial effect exists for the use of angiotensin-converting enzyme inhibitors (ACEIs) and low-protein diets, there is little evidence on whether carbon adsorbent has an effect on retardation of the progression of CRF .
14586729
2003
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
Kidney Failure, Chronic
0.600
Biomarker
RGD
Our findings indicate localized expression of MCP-1 in proximal tubular cells in the remnant kidney and suggest that MCP-1 in proximal tubular cells is involved in tubulointerstitial damage in chronic kidney failure associated with glomerular hypertension.
12080327
2002
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
Kidney Failure, Chronic
0.600
Biomarker
RGD
Only animals from the 1WIK group developed severe chronic renal failure , glomerulosclerosis, interstitial fibrosis, and upregulation of transforming growth factor-beta(1 ) (TGF-beta(1 )) gene, which was associated with increased TGF-beta(1 ) protein expression in tubular epithelial cells, arterioles, and in areas of mononuclear interstitial cell infiltrate.
10919844
2000
×
Entrez Id:
57817
Gene Symbol:
HAMP
HAMP
Kidney Failure, Chronic
0.570
Biomarker
RGD
Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure.
20631677
2010
×
Entrez Id:
1535
Gene Symbol:
CYBA
CYBA
Kidney Failure, Chronic
0.550
Biomarker
RGD
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure.
19420110
2009
×
Entrez Id:
51094
Gene Symbol:
ADIPOR1
ADIPOR1
Kidney Failure, Chronic
0.530
Biomarker
RGD
Changes of adiponectin and its receptors in rats following chronic renal failure.
24028144
2014
SERPINE1
Kidney Failure, Chronic
0.510
Therapeutic
RGD
An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure.
26903149
2016
×
Entrez Id:
5970
Gene Symbol:
RELA
RELA
Kidney Failure, Chronic
0.510
Biomarker
RGD
Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.
18077597
2008
×
Entrez Id:
1536
Gene Symbol:
CYBB
CYBB
Kidney Failure, Chronic
0.510
Biomarker
RGD
Renal tissue abundance of gp91(phox ) subunit of NAD(P)H oxidase was elevated in the untreated CRF group and was partially reduced in the iron dextran-treated CRF group.
15550752
2005
×
Entrez Id:
873
Gene Symbol:
CBR1
CBR1
Kidney Failure, Chronic
0.500
Biomarker
RGD
Effect of experimental kidney disease on the functional expression of hepatic reductases.
25332430
2015
×
Entrez Id:
3156
Gene Symbol:
HMGCR
HMGCR
Kidney Failure, Chronic
0.500
Biomarker
RGD
Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.
21119529
2011
×
Entrez Id:
38
Gene Symbol:
ACAT1
ACAT1
Kidney Failure, Chronic
0.500
Biomarker
RGD
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
19878707
2010
×
Entrez Id:
847
Gene Symbol:
CAT
CAT
Kidney Failure, Chronic
0.500
Biomarker
RGD
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.
20007347
2010
×
Entrez Id:
6721
Gene Symbol:
SREBF2
SREBF2
Kidney Failure, Chronic
0.500
Biomarker
RGD
Despite increased SREBP-2 gene expression we found LDL-receptor mRNA level to be lower than in controls, suggesting SREBP-2 independent mechanisms of LDL-receptor transcriptional regulation in CRF rats.
16814791
2007
×
Entrez Id:
4036
Gene Symbol:
LRP2
LRP2
Kidney Failure, Chronic
0.310
Biomarker
RGD
Modulation of gene expression by moxonidine in rats with chronic renal failure.
15266031
2004
×
Entrez Id:
4846
Gene Symbol:
NOS3
NOS3
Kidney Failure, Chronic
0.300
Therapeutic
RGD
Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease.
29247650
2018
×
Entrez Id:
4846
Gene Symbol:
NOS3
NOS3
Kidney Failure, Chronic
0.300
SusceptibilityMutation
RGD
Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy.
29018182
2017
×
Entrez Id:
5741
Gene Symbol:
PTH
PTH
Kidney Failure, Chronic
0.300
Biomarker
RGD
Two novel vitamin D receptor modulators with similar structures exhibit different hypercalcemic effects in 5/6 nephrectomized uremic rats.
23548814
2013
×
Entrez Id:
6582
Gene Symbol:
SLC22A2
SLC22A2
Kidney Failure, Chronic
0.300
Biomarker
RGD
Protein and mRNA expression levels of Oat1, Oat 3, Oct1, and Oct2 were significantly decreased in adenine-induced CRF rats.
23280877
2013
×
Entrez Id:
5741
Gene Symbol:
PTH
PTH
Kidney Failure, Chronic
0.300
Biomarker
RGD
Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats.
22517117
2012
×
Entrez Id:
5741
Gene Symbol:
PTH
PTH
Kidney Failure, Chronic
0.300
Biomarker
RGD
The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.
21826734
2011
×
Entrez Id:
6569
Gene Symbol:
SLC34A1
SLC34A1
Kidney Failure, Chronic
0.300
Biomarker
RGD
The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.
21826734
2011
×
Entrez Id:
8074
Gene Symbol:
FGF23
FGF23
Kidney Failure, Chronic
0.300
Biomarker
RGD
Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease.
20016468
2010