×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
GeneticVariation
LHGDN
We analyzed TP53 mutations in 193 CLL patients by denaturing high performance liquid chromatography in combination with direct DNA sequencing and a TP53 resequencing research microarray.
18843282
2009
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
GeneticVariation
LHGDN
Out of the 95 patients with CLL , ATM gene deletion was found in 9 (9.5%) patients, TP53 gene deletion in 16 (16.8%) cases.
18035414
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
GeneticVariation
LHGDN
The overexpression of "delta ex6" p53 variant in CLL patients supports the recent evidence on dysregulation of p53 splicing pattern in malignancies.
17688945
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
AlteredExpression
LHGDN
We studied 126 well-characterized CLL patients by direct sequencing and DHPLC to detect TP53 mutations (exons 2-11).
18689542
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
GeneticVariation
LHGDN
Further studies are required to understand the role of SNPs in the p53 pathway in CLL .
17981213
2007
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
GeneticVariation
LHGDN
Translocations or isochromosome formations at sites of low-copy DNA repeats in 17p10 to 17p12 appear to be the mechanism for the loss of TP53 in B-CLL .
16737921
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
Chronic Lymphocytic Leukemia
0.800
Biomarker
LHGDN
Thus, p53 appears to be part of the survival pathway induced by alpha4beta1 ligation and may contribute to the progressive drug resistance in B-CLL .
14623330
2003
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
Chronic Lymphocytic Leukemia
0.700
GeneticVariation
LHGDN
Out of the 95 patients with CLL , ATM gene deletion was found in 9 (9.5%) patients, TP53 gene deletion in 16 (16.8%) cases.
18035414
2008
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
Chronic Lymphocytic Leukemia
0.700
Biomarker
LHGDN
ATM mutations in B-cell chronic lymphocytic leukemia .
14754616
2004
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
Chronic Lymphocytic Leukemia
0.700
GeneticVariation
LHGDN
To examine this proposition further we have screened the ATM gene for mutations in CLL s from 61 individuals in 29 families.
12091354
2002
IGHV3-21
Chronic Lymphocytic Leukemia
0.600
AlteredExpression
LHGDN
The first one (7 of 16 cases) carried a similar HCDR3 amino acid sequence (common-HCDR3 subset), virtually identical to the Scandinavian IGHV3-21 CLL .
15466924
2005
×
Entrez Id:
5027
Gene Symbol:
P2RX7
P2RX7
Chronic Lymphocytic Leukemia
0.590
GeneticVariation
LHGDN
Activation of the P2X7 receptor leads to apoptosis of lymphocytes in individuals with CLL , and reduced function of this receptor has an anti-apoptotic effect, resulting in an increase in B-cell numbers.
11943260
2002
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
Chronic Lymphocytic Leukemia
0.500
Biomarker
LHGDN
Surface expression of Bcl-2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14;18).
18633450
2008
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
Chronic Lymphocytic Leukemia
0.500
GeneticVariation
LHGDN
Prognostic assessment of BCL2 -938C>A polymorphism in chronic lymphocytic leukemia .
18156504
2008
×
Entrez Id:
596
Gene Symbol:
BCL2
BCL2
Chronic Lymphocytic Leukemia
0.500
AlteredExpression
LHGDN
In CD19+ B-CLL cells, the Bax/Bcl-2 ratio was lower than in the CD19+ normal counterpart (1.3 versus 3.51; P<.05), mainly due to a Bcl-2 over expression (17.65 versus 9.02; P<.001).
17118768
2006
×
Entrez Id:
3676
Gene Symbol:
ITGA4
ITGA4
Chronic Lymphocytic Leukemia
0.400
Biomarker
LHGDN
Our observations indicate CD49d >or=30% as a new marker for the initial prognostic assessment of Binet A chronic lymphocytic leukemia .
18641015
2008
×
Entrez Id:
3676
Gene Symbol:
ITGA4
ITGA4
Chronic Lymphocytic Leukemia
0.400
AlteredExpression
LHGDN
These findings support the introduction of CD49d detection in routine prognostic assessment of CLL patients, and suggest both pathogenetic and therapeutic implications for CD49d expression in CLL .
17959854
2008
×
Entrez Id:
921
Gene Symbol:
CD5
CD5
Chronic Lymphocytic Leukemia
0.400
Biomarker
LHGDN
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
17878328
2007
×
Entrez Id:
3676
Gene Symbol:
ITGA4
ITGA4
Chronic Lymphocytic Leukemia
0.400
Biomarker
LHGDN
CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium.
15731179
2005
×
Entrez Id:
921
Gene Symbol:
CD5
CD5
Chronic Lymphocytic Leukemia
0.400
GeneticVariation
LHGDN
We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL ) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples.
15981803
2005
×
Entrez Id:
330
Gene Symbol:
BIRC3
BIRC3
Chronic Lymphocytic Leukemia
0.400
AlteredExpression
LHGDN
Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia.
15183896
2004
×
Entrez Id:
3676
Gene Symbol:
ITGA4
ITGA4
Chronic Lymphocytic Leukemia
0.400
Biomarker
LHGDN
Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine.
14623330
2003
×
Entrez Id:
921
Gene Symbol:
CD5
CD5
Chronic Lymphocytic Leukemia
0.400
GeneticVariation
LHGDN
CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity?
12447961
2002
×
Entrez Id:
3676
Gene Symbol:
ITGA4
ITGA4
Chronic Lymphocytic Leukemia
0.400
Biomarker
LHGDN
The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.
11929789
2002
TNFRSF11A
Chronic Lymphocytic Leukemia
0.330
Biomarker
LHGDN
Since IL-8 has been implicated in progression of B-CLL disease, our findings suggest that, by upregulating IL-8, the RANKL/RANK system may contribute to the pathogenesis of B-CLL .
16270354
2006