Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.700 Biomarker RGD Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma. 29429512

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.690 Biomarker RGD Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. 16317707

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.690 Biomarker RGD De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats. 12359353

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.690 Biomarker RGD Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carcinoma. 11301474

2001

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.660 Biomarker RGD Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. 8446626

1993

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Biomarker RGD Mechanistic study on liver tumor promoting effects of flutamide in rats. 22076107

2012

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.600 Therapeutic RGD Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats. 22129741

2011

Entrez Id: 5465
Gene Symbol: PPARA
PPARA
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.580 SusceptibilityMutation RGD PPAR-alpha L162V polymorphism in human hepatocellular carcinoma. 19119483

2008

Entrez Id: 7015
Gene Symbol: TERT
TERT
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.550 Biomarker RGD Nuclear translocation of telomerase reverse transcriptase: a critical process in chemical induced hepatocellular carcinogenesis. 20353272

2010

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.540 Biomarker RGD Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. 17554210

2007

Entrez Id: 7039
Gene Symbol: TGFA
TGFA
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.530 Biomarker RGD Hepatocellular neoplasms induced by low-number pancreatic islet transplants in streptozotocin diabetic rats. 9060843

1997

Entrez Id: 2272
Gene Symbol: FHIT
FHIT
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.510 Biomarker RGD Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. 12112319

2002

Entrez Id: 440
Gene Symbol: ASNS
ASNS
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.500 Biomarker RGD L-Asparagine synthetase in serum as a marker for neoplasia. 10081

1976

Entrez Id: 2719
Gene Symbol: GPC3
GPC3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.380 Therapeutic RGD Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. 25449037

2015

Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.320 Biomarker RGD [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. 18971187

2008

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.300 Biomarker RGD Verapamil and rifampin effect on p-glycoprotein expression in hepatocellular carcinoma. 25625052

2014

Entrez Id: 3172
Gene Symbol: HNF4A
HNF4A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.300 Biomarker RGD Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. 20876809

2010

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.300 Therapeutic RGD [Prevention of hepatic tumor growth and metastasis in rats with rapamycin]. 19335982

2009

Entrez Id: 80781
Gene Symbol: COL18A1
COL18A1
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.300 ModifyingMutation RGD Employing an appropriate rat hepatoma model, we examined the effects of sFlt-1 (soluble vascular endothelial growth factor [VEGF] receptor 1 as an indirect inhibitor of angiogenesis) and endostatin (a direct inhibitor of angiogenesis) in both single-agent as well as combined approaches under in vitro and in vivo conditions. 15739185

2005

Entrez Id: 57817
Gene Symbol: HAMP
HAMP
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.280 Biomarker RGD Hepcidin and DNA promoter methylation in hepatocellular carcinoma. 29235098

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.270 Biomarker RGD Additionally, we show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management. 29610518

2018

Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.270 Biomarker RGD Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. 23633480

2013

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.260 Therapeutic RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031

2018

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.260 Biomarker RGD Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. 18373278

2008

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.260 Biomarker RGD Specificity for the binding of the molecularly targeted anti-c-MET contrast agent was determined using rat hepatoma (H4-II-E-C3) cell cultures and immunofluorescence microscopic imaging of the targeting agents within neoplastic liver tissue 1 to 2 hours following intravenous administration of SPIO-anti-c-MET and MRI investigation. 17311762

2007