Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Genomic landscape of cutaneous T cell lymphoma. 26192916

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. 20727180

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. 20727180

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat. 20135361

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human DNA methylation markers and early recurrence in stage I lung cancer. 18337602

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers. 17325666

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers. 17325666

2007

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human The incidence of KRAS2 mutations in human compared to mouse lung tumors differed significantly, as did the incidence of Hras and p53 gene mutations in human compared to mouse liver tumors. 16410370

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human The incidence of KRAS2 mutations in human compared to mouse lung tumors differed significantly, as did the incidence of Hras and p53 gene mutations in human compared to mouse liver tumors. 16410370

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: a prospective study in high-risk patients without invasive cancer. 12115568

2002

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human Methylation of the p16 and ER genes was very common (80 and 50%, respectively) in beryllium-induced lung tumors; both genes were methylated in 40% of the tumors. 11872642

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_human [Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82]. 11798837

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Therapeutic CTD_human [Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82]. 11798837

2000

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker CTD_human The ISG15-specific protease USP18 regulates stability of PTEN. 27980214

2017

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.700 Biomarker CTD_human Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. 17909629

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence. 29247004

2018

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. 29106415

2017

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. 27935865

2017

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. 25851810

2015

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2015

Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342

2014

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. 23523951

2013

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. 22028818

2011

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.600 Biomarker CTD_human CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model. 21519798

2011