Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.900 Biomarker MGD A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. 21159799

2011

Entrez Id: 1773
Gene Symbol: DNASE1
DNASE1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.900 Biomarker MGD Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE. 10835632

2000

Entrez Id: 2213
Gene Symbol: FCGR2B
FCGR2B
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.900 Biomarker MGD Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. 10981970

2000

Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.800 Biomarker MGD Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. 16237069

2005

Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.800 Biomarker MGD Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. 10485649

1999

Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.800 Biomarker MGD Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. 9796923

1998

Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.700 Biomarker MGD We established a mutant mouse line bearing MDA5 mutation by ENU mutagenesis, which spontaneously developed lupus-like autoimmune symptoms without viral infection. 24530055

2014

Entrez Id: 720
Gene Symbol: C4A
C4A
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.700 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000

Entrez Id: 712
Gene Symbol: C1QA
C1QA
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.670 Biomarker MGD Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice. 12794146

2003

Entrez Id: 712
Gene Symbol: C1QA
C1QA
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.670 Biomarker MGD Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. 9590289

1998

Entrez Id: 10125
Gene Symbol: RASGRP1
RASGRP1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.620 Biomarker MGD Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. 12932358

2003

Entrez Id: 721
Gene Symbol: C4B
C4B
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.600 Biomarker MGD Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 11067882

2000

Entrez Id: 639
Gene Symbol: PRDM1
PRDM1
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.550 Biomarker MGD

Entrez Id: 50619
Gene Symbol: DEF6
DEF6
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.520 Biomarker MGD Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. 16470246

2006

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. 12486097

2002

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease. 7628400

1995

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjögren's syndrome. 8163351

1994

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Transfer of Sjögren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. 7957574

1994

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. 3009614

1986

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. 6610701

1984

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. 6975351

1981

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice. 6444324

1980

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. 762500

1979

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.400 Biomarker MGD Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. 309911

1978

Entrez Id: 9474
Gene Symbol: ATG5
ATG5
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.390 Biomarker MGD