×
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
Obesity
1.000
Biomarker
MGD
Leptin regulation of bone resorption by the sympathetic nervous system and CART.
15724149 2005
×
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
Obesity
1.000
Biomarker
MGD
Herein, we have identified that voluntary exercise, provided via the presence of a running wheel, impedes the monogenetic obesity (at 20 weeks of age running wheel housed body weight=31+/-1.8 g versus conventionally housed body weight=41+/-2.3 g, a 25% decrease in body weight p<0.01), hyperphagia (average cumulative food intake is not statistically different than wild type mice housed in running wheel cages), and reproductive dysfunction phenotypes associated with the MC4R knockout mice housed by conventional means.
15596147 2005
×
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
Obesity
1.000
Biomarker
MGD
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.
11369941 2001
×
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
Obesity
1.000
Biomarker
MGD
Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note.
10971147 2000
×
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
Obesity
1.000
Biomarker
MGD
Our data identify a novel signaling pathway in the mouse for body weight regulation and support a model in which the primary mechanism by which agouti induces obesity is chronic antagonism of the MC4-R .
9019399 1997
×
Entrez Id: 5443
Gene Symbol: POMC
POMC
Obesity
0.900
Biomarker
MGD
The finding that the loss of only one copy of the Pomc gene is sufficient to render mice susceptible to the effects of high fat feeding emphasizes the potential importance of this locus as a site for gene-environment interactions predisposing to obesity .
15070780 2004
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.
12270926 2002
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function.
9893169 1999
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice.
9019408 1997
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation.
9144234 1997
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
7663508 1995
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
8177043 1994
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
8177042 1994
×
Entrez Id: 1363
Gene Symbol: CPE
CPE
Obesity
0.730
Biomarker
MGD
Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse.
2250094 1991
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.
29551634 2018
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
SHBG-C57BL/ksJ-db/db: A New Mouse Model to Study SHBG Expression and Regulation During Obesity Development.
26441241 2015
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.
24332968 2014
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
Prostaglandin transporter modulates wound healing in diabetes by regulating prostaglandin-induced angiogenesis.
22609345 2012
×
Entrez Id: 3952
Gene Symbol: LEP
LEP
Obesity
0.700
Biomarker
MGD
BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response.
22958920 2012
×
Entrez Id: 3952
Gene Symbol: LEP
LEP
Obesity
0.700
Biomarker
MGD
BTBR Ob/Ob mutant mice model progressive diabetic nephropathy.
20634301 2010
×
Entrez Id: 3952
Gene Symbol: LEP
LEP
Obesity
0.700
Biomarker
MGD
Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse.
19528970 2009
×
Entrez Id: 3952
Gene Symbol: LEP
LEP
Obesity
0.700
Biomarker
MGD
Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation.
19620723 2009
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.
19015522 2008
×
Entrez Id: 3952
Gene Symbol: LEP
LEP
Obesity
0.700
Biomarker
MGD
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.
19103808 2008
×
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
Obesity
0.700
Biomarker
MGD
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance.
17095713 2007