×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
AlteredExpression
LHGDN
Surprisingly, little is known about the role and regulation of hdm2 in pancreatic tumors , a large proportion (50-75%) of which contain mutant p53 .
19029954 2009
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
GeneticVariation
LHGDN
Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations.
18701504 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
GeneticVariation
LHGDN
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
17659731 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
GeneticVariation
LHGDN
Pancreatic tumor cell lines, CRL1420, which contains elevated levels of mutant p53, and CRL1682, with no detectable p53 protein, were stably transfected with the exogenous wild-type p53 gene.17651038 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
AlteredExpression
LHGDN
Expression of Gadd45a and p53 proteins in human pancreatic cancer: potential effects on clinical outcomes.
17230496 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
GeneticVariation
LHGDN
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
17106238 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Pancreatic Neoplasm
0.900
GeneticVariation
LHGDN
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
15846069 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
GeneticVariation
LHGDN
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
18714178 2008
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
Biomarker
LHGDN
Genetic testing in familial melanoma: uptake and implications.
18613292 2008
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
GeneticVariation
LHGDN
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
17106238 2006
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
Biomarker
LHGDN
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.
15985168 2005
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
AlteredExpression
LHGDN
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
15336553 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
Biomarker
LHGDN
INK4/ARF germline alterations in pancreatic cancer patients.
14679123 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
GeneticVariation
LHGDN
Familial melanoma, pancreatic cancer and germline CDKN2A mutations.
15146471 2004
×
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
Pancreatic Neoplasm
0.800
GeneticVariation
LHGDN
High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.
11807902 2002
×
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Pancreatic Neoplasm
0.700
AlteredExpression
LHGDN
Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells.
18519681 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
Biomarker
LHGDN
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.
18549880 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection.
18075308 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
Shining the spotlight on shed KRAS in pancreatic cancer.
18614859 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
17198183 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations.
18049799 2006
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
15846069 2005
×
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Pancreatic Neoplasm
0.700
AlteredExpression
LHGDN
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
15846069 2005
×
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
15014009 2004
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Pancreatic Neoplasm
0.700
GeneticVariation
LHGDN
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
15112354 2004