Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker LHGDN Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet. 17383860

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker LHGDN A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects. 16987250

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 GeneticVariation LHGDN The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders. 16026766

2005

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker LHGDN Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia. 15522255

2004

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease. 18282107

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects. 17870056

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Progressive reductions of subcortical 5-HT(2A)R density could provide an indicator of illness activity and help to predict imminent conversion to schizophrenia. 17899021

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker LHGDN Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting. 17924589

2008

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker LHGDN Our results strongly support a previous hypothesis that NOS1 contributes to the genetic risk of schizophrenia and suggest that further research on more NOS1 variants and its regular elements are warranted. 18544180

2008

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN There may be association between CHRNA7 gene polymorphisms and schizophrenia, the variant allele T in rs2337980 may have a protective effect to schizophrenia. 18393235

2008

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker LHGDN Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. 17989066

2008

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Our findings suggest that allelic variants of RELN contribute to the endophenotypes of schizophrenia. 17684500

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN We analyzed the 5-HT(2A)R A-1438G, T102C, and H452Y polymorphisms and assessed startle reactivity, habituation, and PPI of ASR in 68 Caucasian schizophrenia inpatients. 18420180

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia. 17221846

2007

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. 17884806

2007

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN In conclusion, our replication study provides further evidence for association between the 5-HTR2A receptor T102C polymorphism and schizophrenia. 17240119

2007

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN The results of the present study seem to indicate that HTR2A gene polymorphism influences the tendency to express TD following prolonged antipsychotic drug exposure in Turkish schizophrenia patients. 17688403

2007

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression LHGDN These findings establish the major cell types wherein serine racemase and D-amino acid oxidase are expressed in human brain and provide some support for aberrant D-serine metabolism in schizophrenia. 17880399

2007

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN We analysed the 5-HTR2A T102C and A-1438G polymorphisms in clinically stable schizophrenia patients (SPs) and healthy volunteers (HVs). 17617023

2007

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach. 17521439

2007

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN Characterization of allelic variants at chromosome 15q14 in schizophrenia. 16417613

2006

Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker LHGDN The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338

2006

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression LHGDN We studied the expression of serine racemase, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. 16837850

2006

Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation LHGDN These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005. 15841096

2005

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker LHGDN Distribution volume ratios (DVRs) as a proxy for 5-HT(2A)R availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia. 16187138

2005