Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.720 Biomarker RGD CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. 25457025

2015

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.590 Biomarker RGD The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations. 20649973

2010

Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.570 Therapeutic RGD The aim of this study was to investigate the effect of gamma-Glutamylcysteine Ethyl Ester (GCEE) on the levels of GSH, caspase-3 activity, DNA damage and the expressions of Bcl-2, Bax and p53 mRNAs in rat hippocampus after status epilepticus (SE) induced by systemic kainic acid (KA). 20214503

2010

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.560 Biomarker RGD On the other hand, if seizures were induced at the time endogenous BDNF was increased, SE-induced neuronal damage was exacerbated. 19686240

2009

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.560 Biomarker RGD Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. 19366663

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.550 Biomarker RGD A 3-day treatment with the cox-2 inhibitor SC-58236 (SC) was started 1 day before electrically induced SE. 20643531

2010

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.510 Biomarker RGD Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE. 20971094

2011

Entrez Id: 1756
Gene Symbol: DMD
DMD
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.510 Biomarker RGD These findings suggest that SE may induce impairments of astroglial AQP4 functions via disruption of the dystrophin/α-syntrophin complex that worsen vasogenic edema. 20886625

2010

Entrez Id: 1268
Gene Symbol: CNR1
CNR1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.510 Biomarker RGD The data indicate that overall decreases in expression following SE preempt a long-lasting CB(1) receptor redistribution, and that differential responses occur within the hippocampus to initial CB(1) receptor losses. 19368833

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.510 Biomarker RGD Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus. 17950261

2007

Entrez Id: 6348
Gene Symbol: CCL3
CCL3
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Characterization of the expression of macrophage inflammatory protein-1α (MIP-1α) and C-C chemokine receptor 5 (CCR5) after kainic acid-induced status epilepticus (SE) in juvenile rats. 22248156

2012

Entrez Id: 361
Gene Symbol: AQP4
AQP4
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD These findings suggest that SE may induce impairments of astroglial AQP4 functions via disruption of the dystrophin/α-syntrophin complex that worsen vasogenic edema. 20886625

2010

Entrez Id: 6640
Gene Symbol: SNTA1
SNTA1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. 20886625

2010

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Long-term increasing co-localization of SCN8A and ankyrin-G in rat hippocampal cornu ammonis 1 after pilocarpine induced status epilepticus. 19306853

2009

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E. 19138675

2009

Entrez Id: 6754
Gene Symbol: SSTR4
SSTR4
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Both SSTR2B and SSTR4 immunoreactivities were increased within microglia following SE. 18951627

2009

Entrez Id: 4208
Gene Symbol: MEF2C
MEF2C
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD It was demonstrated that MEF2C is up-regulated during development (P0, P3, P7, P14 and P28) and in the adult rat dentate gyrus following SE (3, 7, 14, 28 days after SE). 18949272

2008

Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. 16504477

2006

Entrez Id: 6714
Gene Symbol: SRC
SRC
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505

2006

Entrez Id: 2185
Gene Symbol: PTK2B
PTK2B
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-induced tyrosine phosphorylation. 16600505

2006

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Hippocampal-parahippocampal protein expression of NCX1, 2, and 3, PMCA1-4, and NCKX2 at an early and late stage after kainate-induced status epilepticus (SE) was compared with that in control rats by using immunocytochemistry. 15461673

2004

Entrez Id: 6547
Gene Symbol: SLC8A3
SLC8A3
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus. 15461673

2004

Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.500 Biomarker RGD Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. 15036620

2004

Entrez Id: 5428
Gene Symbol: POLG
POLG
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.370 Biomarker RGD Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. 18295498

2008

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.300 Biomarker RGD Thereafter, spontaneous convulsions (SCs), mossy fiber sprouting (MFS), neuronal loss, activation of microglia and astrocytes, expressions of interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) were evaluated in the SE rats. 22960129

2012