Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Therapeutic RGD Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. 29180187

2017

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. 27598601

2016

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Therapeutic RGD Effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) pretreatment on septic rats. 24055021

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Therapeutic RGD Effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) pretreatment on septic rats. 24055021

2013

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats. 20132852

2010

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD [Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats]. 19489280

2009

Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Therapeutic RGD Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. 19623040

2009

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis. 19371254

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD [Changes in expressions of the myocardial Toll-like receptor 4, tumor necrosis factor-alpha and interleukin-6 mRNA in rat with sepsis]. 19695174

2009

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. 15665729

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. 15665729

2005

Entrez Id: 5624
Gene Symbol: PROC
PROC
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 ModifyingMutation RGD Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. 15241104

2004

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker RGD [Changes in Toll-like receptor 2 and 4 gene expression in vital organs in septic rats and their regulation mechanisms]. 14604479

2003

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0243026
Disease: Sepsis
Sepsis
0.540 Therapeutic RGD Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood-brain barrier dysfunction in an animal model of severe sepsis. 23479197

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. 27598601

2016

Entrez Id: 2152
Gene Symbol: F3
F3
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD Sodium tanshinone II A sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis. 26311287

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD Moxifloxacin-loaded nanoemulsions having tocopheryl succinate as the integral component improves pharmacokinetics and enhances survival in E. coli-induced complicated intra-abdominal infection. 25317848

2014

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD [Effect of oxymatrine on JAK2/STAT3 signaling in renal tissues of rats with septic shock]. 24228589

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD Activated protein C alters inflammation and protects renal function in sepsis. 21429520

2011

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD A model of experimental acute hematogenous pyelonephritis in the rat. 21797109

2011

Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis. 20451670

2010

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. 19623040

2009

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD [Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats]. 19489280

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD The role of redox status on chemokine expression in acute pancreatitis. 19111613

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes. 19079684

2008