Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.600 Biomarker CTD_mouse PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042

2014

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.560 Biomarker RGD Osteopontin expression in intratumoral astrocytes marks tumor progression in gliomas induced by prenatal exposure to N-ethyl-N-nitrosourea. 16651633

2006

Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.500 Biomarker MGD

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.260 Biomarker RGD Antitumor effects of monoclonal antibodies to connexin 43 extracellular fragment in induced low-differentiated glioma. 22808518

2012

Entrez Id: 208
Gene Symbol: AKT2
AKT2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.260 Biomarker RGD Reduction of Akt2 inhibits migration and invasion of glioma cells. 19330838

2009

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.260 Therapeutic RGD Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. 19292920

2009

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.220 Biomarker RGD In vivo detection of c-Met expression in a rat C6 glioma model. 18194445

2008

Entrez Id: 3371
Gene Symbol: TNC
TNC
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.220 Biomarker RGD Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo. 16928692

2006

Entrez Id: 285
Gene Symbol: ANGPT2
ANGPT2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. 18615861

2008

Entrez Id: 2833
Gene Symbol: CXCR3
CXCR3
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma. 16434036

2006

Entrez Id: 63827
Gene Symbol: BCAN
BCAN
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. 12799382

2003

Entrez Id: 63827
Gene Symbol: BCAN
BCAN
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 ModifyingMutation RGD Brain enriched hyaluronan binding (BEHAB)/brevican increases aggressiveness of CNS-1 gliomas in Lewis rats. 11585735

2001

Entrez Id: 6480
Gene Symbol: ST6GAL1
ST6GAL1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Therapeutic RGD Thus, manipulating ST6Gal I gene expression may have therapeutic potential for the treatment of malignant gliomas. 11559557

2001

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.210 Biomarker RGD Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells. 10078962

1999

Entrez Id: 10533
Gene Symbol: ATG7
ATG7
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Therapeutic RGD Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas. 25542083

2015

Entrez Id: 22933
Gene Symbol: SIRT2
SIRT2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Therapeutic RGD Ultrasound-sensitive siRNA-loaded nanobubbles formed by hetero-assembly of polymeric micelles and liposomes and their therapeutic effect in gliomas. 23522375

2013

Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 ModifyingMutation RGD In malignant glioma, however, galectin-3 was expressed in both neoplastic astrocytic cells and microglia. 23179497

2013

Entrez Id: 6455
Gene Symbol: SH3GL1
SH3GL1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 ModifyingMutation RGD Autologous antibody to src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. 23050879

2012

Entrez Id: 858
Gene Symbol: CAV2
CAV2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Low-frequency ultrasound irradiation increases blood-tumor barrier permeability by transcellular pathway in a rat glioma model. 22528460

2012

Entrez Id: 4288
Gene Symbol: MKI67
MKI67
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Evaluation of biocompatibility and anti-glioma efficacy of doxorubicin and irinotecan drug-eluting bead suspensions in alginate. 22262719

2012

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Low-frequency ultrasound irradiation increases blood-tumor barrier permeability by transcellular pathway in a rat glioma model. 22528460

2012

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Targeting the erythropoietin receptor on glioma cells reduces tumour growth. 21749867

2011

Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study. 20080302

2010

Entrez Id: 1508
Gene Symbol: CTSB
CTSB
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. 17287256

2007

Entrez Id: 8877
Gene Symbol: SPHK1
SPHK1
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma
0.200 Biomarker RGD Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. 17316399

2007