Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker PSYGENET Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.700 Biomarker PSYGENET Genetic variation in CACNA1C affects neural processing in major depression. 24612926

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major depressive disorder (MDD) and cognitive function. 26057341

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Our study included 2679 participants.Those with both the 5-HTTLPR s allele and the BDNF Met allele showed the highest risk of MD if they had previously experienced emotional (z = 2.08, p = 0.037), sexual (z = 2.19, p = 0.029) or any kind of childhood abuse (z = 2.37, p = 0.018). 25510949

2015

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518

2015

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients. 25355489

2015

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Single locus analysis in pooled and ethnically stratified subjects revealed no association between each of the three variants of the TPH2 gene with susceptibility to MDD. 24376086

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET182C) polymorphisms are associated with susceptibility and treatment response in major depressive disorder (MDD). 25650523

2015

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis. 25270656

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET We therefore investigated whether variation in hippocampus, amygdala, orbitofrontal cortex (OFC) and anterior cingulate cortex volumes at age 12 years mediated a putative association between 5-HTTLPR genotype and first onset of major depressive disorder (MDD) between age 13-19 years, in a longitudinal study of 174 adolescents (48% males). 25226554

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD. 24972302

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. 24962835

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008). 25108775

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress. 25522420

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie 102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD. 24801750

2014

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET This analysis suggests that DNA hypomethylation of the 5-HTT transcriptional control region - possibly via increased serotonin transporter expression and consecutively decreased serotonin availability - might impair antidepressant treatment response in Caucasian patients with MDD. 24679990

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Genetic variations in the co-chaperone FK506-binding protein 51, FKBP5, which modulates the function of glucocorticoid receptors, have been associated with an increased risk for the development of posttraumatic stress disorder, but data regarding its role in MDD are controversial. 23861224

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355

2013

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels. 23336047

2013