Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253

2014

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. 19184424

2010

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human As the finding of pathogenic CDH1 mutations is useful for management of HDGC families, screening for deletions should be offered to at-risk families. 19168852

2009

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human Direct evidence of E-cadherin mutations triggering tumorigenesis has come from the finding of inactivating germline mutations of the gene (CDH1) in hereditary diffuse gastric cancer (HDGC). 12588804

2003

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428

1999

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker CTD_human E-cadherin germline mutations in familial gastric cancer. 9537325

1998

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.500 Biomarker CTD_human

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.400 Biomarker CTD_human Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. 11397402

2001

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.400 Biomarker CTD_human DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene. 10874023

2000

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.360 Biomarker CTD_human Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. 24816253

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.360 Biomarker CTD_human Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. 22484628

2012

Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.320 Biomarker CTD_human

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.320 Biomarker CTD_human

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy. 21173787

2012

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients. 21364753

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis. 17171786

2006

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Therapeutic CTD_human "Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells." 15723263

2005

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.310 Biomarker CTD_human "Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells." 15723263

2005

Entrez Id: 1893
Gene Symbol: ECM1
ECM1
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region. 31472228

2019

Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling. 30670679

2019

Entrez Id: 84981
Gene Symbol: MIR22HG
MIR22HG
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.300 Biomarker CTD_human Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling. 30670679

2019