Source: ORPHANET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5308
Gene Symbol: PITX2
PITX2
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.400 GermlineCausalMutation ORPHANET A novel PITX2c loss-of-function mutation associated with familial atrial fibrillation. 24333117

2014
Entrez Id: 7273
Gene Symbol: TTN
TTN
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 SusceptibilityMutation ORPHANET Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation. 30333491

2018
Entrez Id: 4635
Gene Symbol: MYL4
MYL4
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. 27066836

2016
Entrez Id: 137814
Gene Symbol: NKX2-6
NKX2-6
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 SusceptibilityMutation ORPHANET NKX2-6 mutation predisposes to familial atrial fibrillation. 25319568

2014
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. 24582607

2014
Entrez Id: 140628
Gene Symbol: GATA5
GATA5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation. 23175127

2013
Entrez Id: 6330
Gene Symbol: SCN4B
SCN4B
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutations of the SCN4B-encoded sodium channel β4 subunit in familial atrial fibrillation. 23604097

2013
Entrez Id: 1482
Gene Symbol: NKX2-5
NKX2-5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET A novel NKX2.5 loss-of-function mutation responsible for familial atrial fibrillation. 23525379

2013
Entrez Id: 2627
Gene Symbol: GATA6
GATA6
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Prevalence and spectrum of GATA6 mutations associated with familial atrial fibrillation. 22257684

2012
Entrez Id: 2626
Gene Symbol: GATA4
GATA4
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutation spectrum of the GATA4 gene in patients with idiopathic atrial fibrillation. 22552926

2012
Entrez Id: 1482
Gene Symbol: NKX2-5
NKX2-5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. 22818067

2012
Entrez Id: 3784
Gene Symbol: KCNQ1
KCNQ1
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. 22471742

2012
Entrez Id: 140628
Gene Symbol: GATA5
GATA5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Novel GATA5 loss-of-function mutations underlie familial atrial fibrillation. 23295592

2012
Entrez Id: 2627
Gene Symbol: GATA6
GATA6
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Novel GATA6 loss-of-function mutation responsible for familial atrial fibrillation. 22824924

2012
Entrez Id: 2627
Gene Symbol: GATA6
GATA6
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET GATA6 loss-of-function mutation in atrial fibrillation. 22750565

2012
Entrez Id: 3753
Gene Symbol: KCNE1
KCNE1
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GeneticVariation ORPHANET Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. 22471742

2012
Entrez Id: 140628
Gene Symbol: GATA5
GATA5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutational spectrum of the GATA5 gene associated with familial atrial fibrillation. 22483626

2012
Entrez Id: 2626
Gene Symbol: GATA4
GATA4
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET GATA4 loss-of-function mutations in familial atrial fibrillation. 21708142

2011
Entrez Id: 55800
Gene Symbol: SCN3B
SCN3B
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. 21051419

2011
Entrez Id: 2626
Gene Symbol: GATA4
GATA4
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Novel GATA4 mutations in lone atrial fibrillation. 21874226

2011
Entrez Id: 2702
Gene Symbol: GJA5
GJA5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Novel connexin40 missense mutations in patients with familial atrial fibrillation. 20650941

2010
Entrez Id: 55800
Gene Symbol: SCN3B
SCN3B
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. 20558140

2010
Entrez Id: 6324
Gene Symbol: SCN1B
SCN1B
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GeneticVariation ORPHANET Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. 19808477

2009
Entrez Id: 3741
Gene Symbol: KCNA5
KCNA5
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. 19343045

2009
Entrez Id: 6327
Gene Symbol: SCN2B
SCN2B
CUI: C1843687
Disease: ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 		0.300 GermlineCausalMutation ORPHANET Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. 19808477

2009