Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. 24931706

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET These data are the first in vivo evidence of a role for chromatin modifications in the regulation of Crhr1 gene expression in the hypothalamus, and may provide novel insight into therapeutic approaches to treat depression. 24867333

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5-HTTLPR. 25422958

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders. 23962971

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.600 Biomarker PSYGENET These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. 22467522

2012

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis. 24933348

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5-HTTLPR. 25422958

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. 24931706

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker PSYGENET These data are the first in vivo evidence of a role for chromatin modifications in the regulation of Crhr1 gene expression in the hypothalamus, and may provide novel insight into therapeutic approaches to treat depression. 24867333

2015

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET This work provides support for a model in which CRHR1 gene variation modulates the risk of problem drinking via an internalizing/negative affect pathway involving rVLPFC and reappraisal of negative emotion. 24623788

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Ongoing clinical trials with pexacerfont and verucerfont in moderately to highly severe dependent anxious alcoholics may yield insight as to the role of CRF(1) receptor antagonists in a personalized medicine approach to treat drug or alcohol dependence. 23294766

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence. 23220399

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET This study extends the literature on the interplay between CRHR1 variation and alcoholism, in the context of exposure to traumatic stress. 23473364

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.400 Biomarker PSYGENET The goals of this commentary are to discuss the important contributions of the work by Kaur and colleagues titled Corticotropin-releasing factor acting on corticotropin-releasing factor receptor type 1 is critical for binge alcohol drinking in mice, published in this issue of Alcoholism: Clinical and Experimental Research, and to highlight the importance of preclinical research aimed at identifying the neurobiology of binge ethanol drinking. 22283808

2012

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.350 Biomarker PSYGENET Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders. 23962971

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.350 Biomarker PSYGENET Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD). 22249355

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.350 Biomarker PSYGENET To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV. 23157339

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.350 Biomarker PSYGENET These results suggest that the CRHR1 gene could modify the susceptibility to developing recurrent MDD following negative life events in adulthood. 23529111

2013

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.350 Biomarker PSYGENET These results provide support for an association of CRHR1 and CRHR2 with MDD and PD. 22467522

2012