Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. 22230815

2012

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional specificity of different ER subtypes in the protective actions of estrogen in aldosterone (Aldo)-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Site-specific paraventricular nucleus (PVN) or rostroventrolateral medulla (RVLM) injections of siRNA-ERβ augmented Aldo-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD These results indicate that both PVN and RVLM ERβ, but not ERα in these nuclei, contribute to the protective effects of estrogen against Aldo-induced hypertension. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD In contrast, intracerebroventricular injections of siRNA-ERα or siRNA-ERβ augmented Aldo-induced hypertension in intact females. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.250 Biomarker RGD Intracerebroventricular infusions of either diarylpropionitrile, a selective ERβ agonist, or propyl-pyrazole-triol, a selective ERα agonist, attenuated Aldo/NaCl-induced hypertension in ovariectomized rats. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.250 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2009

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.240 Therapeutic RGD Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. 24128867

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD These data indicate that ERβ and OT interact to modulate the HPA reactivity and the display of anxiety-like behaviors. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD It is known, however, that estrogen receptor β (ERβ) inhibits HPA reactivity and decreases anxiety-like behavior in rodents. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD Since ERβ is co-expressed with oxytocin (OT) in neurons of the PVN, an ERβ-selective agonist was utilized to test the whether ERβ decreases stress-induced HPA reactivity and anxiety-like behaviors via an OTergic pathway. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD When tested for anxiety-like behavior on the elevated plus maze (EPM), diarylpropionitrile-treated males and females significantly increased time on the open arm of the EPM compared to vehicle controls indicating that ERβ reduces anxiety-like behaviors. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats. 24015243

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.230 Therapeutic RGD Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.220 Biomarker RGD This study suggests a potential role for ERβ signaling in the modulation of epithelial permeability and demonstrates reduced ERβ mRNA in animal models of colitis and colon of patients with inflammatory bowel disease. 21252046

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.220 Biomarker RGD Expression of ERβ and proinflammatory cytokines was investigated in colonic biopsies from IBD patients. 21252046

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.220 Biomarker RGD Decreased ERβ mRNA levels were observed in colonic biopsies from IBD patients. 21252046

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0004096
Disease: Asthma
Asthma
0.220 Biomarker RGD ERB-041 [7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol], an ERbeta agonist, was profiled on cytokine release from interleukin-1beta-stimulated human airway smooth muscle (HASM) cells and in the rodent asthma model. 18375789

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.220 Biomarker RGD However, ERB-041 has a dramatic beneficial effect in the HLA-B27 transgenic rat model of inflammatory bowel disease and the Lewis rat adjuvant-induced arthritis model. 14500559

2003

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0154455
Disease: Other anxiety states
Other anxiety states
0.200 Therapeutic RGD Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats. 24015243

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0154455
Disease: Other anxiety states
Other anxiety states
0.200 Therapeutic RGD Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β. 23593292

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029823
Disease: Other specified peritonitis
Other specified peritonitis
0.200 Therapeutic RGD Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. 23063870

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
Other specified transient cerebral ischemias
0.200 Biomarker RGD Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β. 23593292

2013