Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker RGD "[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]." 24812904

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease. 23378761

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker RGD Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response. 23159984

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. 23237935

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker RGD Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. 23143013

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker RGD Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. 22963993

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009319
Disease: Colitis
Colitis
0.600 Biomarker RGD Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 22969190

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker RGD Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats. 22265659

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker RGD Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine. 23132788

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker RGD Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. 21173343

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.600 Biomarker RGD Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model. 20476872

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis
0.600 Biomarker RGD Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. 19945540

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0015967
Disease: Fever
Fever
0.600 Biomarker RGD In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. 16455768

2006

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.600 Biomarker RGD Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system. 15894892

2005

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. 15000880

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker RGD A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. 15317861

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Therapeutic RGD The results showed that intraplantar injection of carrageenan led to time-dependent development of peripheral inflammation, which resulted in a significant increase in the levels of tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) β, nitric oxide (NO) and prostaglandin E2 (PGE2) and also iNOS and COX-2 protein expression in inflamed paw. 26069367

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Therapeutic RGD The galactose-binding lectin isolated from Bauhinia bauhinioides Mart seeds inhibits neutrophil rolling and adhesion via primary cytokines. 25706245

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Biomarker RGD Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body. 22994521

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Biomarker RGD alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat. 17676395

2008

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Biomarker RGD The aim of the present study was to test the hypothesis that IL-1beta mediates the functional consequences of inflammation during the course of delayed-type hypersensitivity response to bacillus Calmette-Guérin (BCG) in the hippocampus of Lewis rats. 15050649

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 Biomarker RGD Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats. 19948880

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003123
Disease: Anorexia
Anorexia
0.530 Biomarker RGD Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats. 22902858

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Therapeutic RGD Ellagic Acid Prevents Oxidative Stress, Inflammation, and Histopathological Alterations in Acrylamide-Induced Hepatotoxicity in Wistar Rats. 31342809

2019

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018