Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker PSYGENET Altogether, these findings suggest that these variants in the TIMELESS and RORA genes may confer susceptibility to BD and impact on circadian phenotypes in carriers who thus had lower ability to properly adapt to external cues. 24716566

2014

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker PSYGENET Analysis of clock gene variants revealed that PER3 and RORA genotype predicted period lengthening by Li, whereas GSK3β genotype predicted rhythm effects of Li, specifically among BD cases. 24150227

2013

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.340 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker PSYGENET Genetic and metabolic characterization of insomnia. 21494683

2011

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker PSYGENET We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls. 20072116

2010

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.340 Biomarker PSYGENET Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷), a gene involved in circadian rhythm. 20800221

2010

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.340 Biomarker PSYGENET Polymorphisms in the circadian genes NPAS2, ARNTL, and RORA were also suggested to contribute to depression vulnerability. 19693801

2010

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker PSYGENET Polymorphisms in the circadian genes NPAS2, ARNTL, and RORA were also suggested to contribute to depression vulnerability. 19693801

2010

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker PSYGENET Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷), a gene involved in circadian rhythm. 20800221

2010

Entrez Id: 6095
Gene Symbol: RORA
RORA
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder
0.310 Biomarker PSYGENET The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. 22538398

2012