×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.
25609071 2015
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
RGD
However, the same mutant htt vector caused orexin loss in the hypothalamus - another area known to be affected in HD .
22731249 2012
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.
17715336 2007
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease.
17239451 2007
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
16697652 2006
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's Disease.
15935052 2005
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
RGD
We therefore generated a rat model transgenic of HD , which carries a truncated huntingtin cDNA fragment with 51 CAG repeats under control of the native rat huntingtin promoter.
12620967 2003
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
We have developed a new knock-in mouse model of HD with a chimeric mouse/human exon 1 containing 140 CAG repeats inserted in the murine huntingtin gene.
12926013 2003
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
12223581 2002
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene.
11494364 2001
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Neurological abnormalities in a knock-in mouse model of Huntington's disease.
11152661 2001
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
These changes show glutamine length dependence and dominant inheritance with recruitment of wild-type protein, critical features of the altered HD property that strongly implicate them in the HD disease process and that suggest alternative pathogenic scenarios: the effect of the glutamine tract may act by altering interaction with a critical cellular constituent or by depleting a form of huntingtin essential to medium spiny striatal neurons.
10699173 2000
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice.
10196365 1999
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease.
10533044 1999
×
Entrez Id: 3064
Gene Symbol: HTT
HTT
Huntington Disease
1.000
Biomarker
MGD
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.
7774020 1995