Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0085859
Disease: Polyglandular Type I Autoimmune Syndrome
Polyglandular Type I Autoimmune Syndrome 		1.000 Biomarker MGD Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. 17360567

2007
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0085859
Disease: Polyglandular Type I Autoimmune Syndrome
Polyglandular Type I Autoimmune Syndrome 		1.000 Biomarker MGD Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice lead to autoimmune manifestations that segregate as a monogenic trait, but with wide variation in the spectrum of organs targeted. 16172259

2005
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0085859
Disease: Polyglandular Type I Autoimmune Syndrome
Polyglandular Type I Autoimmune Syndrome 		1.000 Biomarker MGD Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. 15699112

2005
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0085859
Disease: Polyglandular Type I Autoimmune Syndrome
Polyglandular Type I Autoimmune Syndrome 		1.000 Biomarker MGD Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autosomal recessive disease caused by mutations in the AIRE gene. 11854172

2002
Entrez Id: 326
Gene Symbol: AIRE
AIRE
CUI: C0085859
Disease: Polyglandular Type I Autoimmune Syndrome
Polyglandular Type I Autoimmune Syndrome 		1.000 Biomarker MGD Projection of an immunological self shadow within the thymus by the aire protein. 12376594

2002