Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker RGD Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat. 25380250

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome. 25144618

2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Leptin regulates olfactory-mediated behavior in ob/ob mice. 16549076

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. 17130477

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Luminal leptin activates mucin-secreting goblet cells in the large bowel. 16455789

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. 16246967

2005
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. 15331557

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Altered insulin signaling in retinal tissue in diabetic states. 15201286

2004
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. 14578285

2003
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Regulation of myoplasmic Ca(2+) in genetically obese (ob/ob) mouse single skeletal muscle fibres. 12355168

2002
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. 10660043

2000
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion. 7835283

1995
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Threshold for glucose-stimulated insulin secretion in pancreatic islets of genetically obese (ob/ob) mice is abnormally low. 8360782

1993
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Dysregulation of the Hypothalamus-Pituitary-Adrenal Axis in Male and Female, Genetically Obese (ob/ob) Mice. 21554665

1992
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings. 508700

1979
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker MGD Adipocyte size distribution in ob/ob mice during preobese and obese phases of development. 1013161

1976