Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. 28319063

2017

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis. 25959805

2015

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada. 25225577

2014

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. 23657012

2013

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Our results show that mutation analysis of the PALB2 gene, including the analysis of LGRs, is primarily indicated in patients with HBC in case of their BRCA1 and BRCA2 negativity. 24136930

2013

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Given this mutation prevalence and risk, consideration might be given to clinical testing of PALB2 by complete genomic sequencing for familial breast cancer patients with wild-type sequences at BRCA1 and BRCA2. 21285249

2011

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN The PALB2 1592delT mutation has a strong effect on familial breast cancer risk. 19383810

2009

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Here we show, by screening for PALB2 mutations in Finland that a frameshift mutation, c.1592delT, is present at significantly elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. 17287723

2007

Entrez Id: 79728
Gene Symbol: PALB2
PALB2
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial
0.700 Biomarker CLINGEN Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. 16793542

2006