Source: CLINGEN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN Our different biochemical assays yielded no evidence that the eight MLH3 UVs tested are the cause of hereditary colorectal cancer, including Lynch syndrome. 19156873

2009
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair. 19483466

2009
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN MLH3 has been assumed to be less important in MMR than the other HNPCC susceptibility genes MSH2, MSH6, MLH1, and PMS2, and accordingly a low-risk gene for colorectal cancer (CRC). 18521850

2008
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC. 17203173

2007
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair. 16322221

2005
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
CUI: C1333990
Disease: Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer 		0.700 Biomarker CLINGEN Contributions by both MLH1/MLH3 and MLH1/PMS2 complexes to mechanisms of mismatch repair-mediated tumor suppression, therefore, provide an explanation why, among MutL homologues, only germ line mutations in MLH1 are common in hereditary non-polyposis colon cancer. 16204034

2005