Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker CTD_human PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. 26640592

2015

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker CTD_human However, three SNPs in TYR, SILV/CDK2 and ADAMTS20 genes (rs17793678, rs2069398 and rs1510521 respectively) had an overall p-value<0.05 when considering the whole DNA collection (1214 MM cases and 1296 controls). 21559390

2011

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker CTD_human MC1R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. 19578364

2009

Entrez Id: 7299
Gene Symbol: TYR
TYR
CUI: C0025202
Disease: melanoma
melanoma
0.500 Biomarker CTD_human The variant in TYR encoding the R402Q amino acid substitution, previously shown to affect eye color and tanning response, conferred risk of CM (OR = 1.21, P = 2.8 x 10(-7)) and BCC (OR = 1.14, P = 6.1 x 10(-4)). 18488027

2008