Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Here, we have sequenced 38 breast cancer cell lines for mutations in the CHEK2 gene and identified two cell lines with deleterious CHEK2 mutations. 18297428

2009

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human The results are consistent with the hypothesis that CHEK2*1100delC multiplies the risks associated with susceptibility alleles in other genes to increase the risk of breast cancer. 15122511

2004

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581

2003

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human This suggests that the biological mechanisms underlying the elevated risk of breast cancer in CHEK2 mutation carriers are already subverted in carriers of BRCA1 or BRCA2 mutations, which is consistent with participation of the encoded proteins in the same pathway. 11967536

2002