Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human In the current study, next-generation sequencing (NGS) and Sanger Sequencing (SGS) was used for the mutational analysis of PIK3CA in 186 breast carcinomas. 26587011

2015

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Molecular profiling of single circulating tumor cells with diagnostic intention. 25358515

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer. 25267515

2014

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human In this study, we report the development of a knock-in mouse model for breast cancer where the endogenous Pik3ca allele was modified to allow tissue-specific conditional expression of a frequently found Pik3ca(H1047R) (Pik3ca(e20H1047R)) mutant allele. 22370636

2013

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. 21633166

2011

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human In univariate analysis, PI3K pathway aberrations were associated with death from breast cancer; however, this relationship was not maintained in multivariate analysis. 19685490

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human These findings could have important implications for the treatment of PIK3CA-mutant BCs and the development of PI3K/mTOR inhibitors. 20479250

2010

Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.700 Biomarker CTD_human Knockin of mutant PIK3CA activates multiple oncogenic pathways. 19196980

2009