Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Surprisingly, both APOE4 (OR = 4.6, 95% CI = 1.3-16.5) and APOE2 (OR = 7.8, 95% CI = 1.5-40.2) carriers were more likely to meet neuropathologic criteria for AD than those with APOE3/3 genotype. 19255410

2009

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Survival in Alzheimer's disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. 18332630

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN The study of a Spanish case-control sample of 1,183 individuals showed this polymorphism to be associated with AD in an apolipoprotein E (APOE)-specific manner: more specifically, to carry the PSEN1 C allele was associated with a decreased AD risk among carriers of the APOE4 allele. 18957849

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN The aim of this study was to analyze the association of GSTs, including GSTP1, GSTT1 and GSTM1 and apolipoprotein E (apoE) with AD and the distribution of these polymorphisms in the first-degree relatives of patients. 18298341

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN We have described the allele frequencies of the apolipoprotein E gene (APOE) in a large population of patients with AD compared to the frequencies in a cognitively-normal control group, and estimated the effect of the APOE epsilon4 allele on the risk and the age at onset of AD in this population. 18416843

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. 18976728

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease. 18401023

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN The aim of the present work is to investigate the usefulness of cerebrospinal fluid (CSF) beta-amyloid protein (Abeta1-42) and total tau protein (t-tau) analyses in the diagnosis of AD and whether apolipoprotein E (ApoE) epsilon4 allele is a factor for AD affecting Tunisian people. 18555606

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele. 18439297

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN Sialic acid moiety of apolipoprotein E3 at Thr(194) affects its interaction with beta-amyloid(1-42) peptides. 18023277

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN Diabetes and overweight associate with non-APOE4 genotype in an Alzheimer's disease population. 18189240

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype. 18258839

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN We have studied the impact of the apolipoprotein E gene (APOE) on the chromosome 19 linkage peak from an analysis of sib-pairs affected by Alzheimer's disease. 18161859

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Apolipoprotein E polymorphism and brain morphology in mild cognitive impairment. 18843182

2008

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG). 17524782

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN 1.The epsilon 4 allele of the apolipoprotein E gene increases the risk of late onset familial and sporadic Alzheimer disease. 16758323

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Real-time multiplex PCR assay for genotyping of three apolipoprotein E alleles and two choline acetyltransferase alleles with three hybridization probes. 17378730

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers. 17283328

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. 17710250

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, Turkey. 17069783

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. 17822919

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker LHGDN Second, the APOE gene is the only gene so far recognized as a consistent genetic determinant of sporadic forms of AD, even though numerous studies have looked for such genes; these disappointing results suggest persistent methodological limitations. 17659844

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia? 17539949

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN APOE genotype and cholesterol levels in lewy body dementia and Alzheimer disease: investigating genotype-phenotype effect on disease risk. 16956959

2006

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation LHGDN ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease. 16480703

2006