Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Rheumatoid arthritis patients showed high TNFalpha mRNA expression (1.33-fold). 18797411

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. 18381799

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. 18668547

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. 19017992

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population. 17562093

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Rheumatoid arthritis, periodontal disease and coronary artery disease. 17763921

2008

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. 17343250

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN TNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombians. 17631742

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Increased nuclear factor-kappaB activation in peripheral blood monocytes of patients with rheumatoid arthritis is mediated primarily by tumor necrosis factor-alpha. 17896809

2007

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? 16446172

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis. 16820934

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha. 16936264

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. 16564576

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. 16751383

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells. 16569263

2006

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans. 15725578

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor. 15723199

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN [Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives]. 14979058

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype. 12528108

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. 11838837

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. 12091338

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Regulation of TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappaB in synoviocytes obtained from patients with rheumatoid arthritis. 12067756

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. 11861275

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases. 11725485

2001